Paladini G, Sala P G
Acta Haematol. 1979;62(3):148-52. doi: 10.1159/000207561.
The anion gap was evaluated in 26 consecutive patients with multiple myeloma (15 IgG and 11 IgA). The average union gap was found reduced only in IgG myeloma. Instead, in the subjects with IgA myeloma it resulted as increased. The partial differences between our results and those of other authors are discussed. The finding of correlations between the anion gaps and paraproteinemic concentrations (direct in IgA myeloma, inverse in IgG myeloma) gives further support to the conception that the charge exhibited in the serum by IgG and IgA paraproteins is, respectively, positive and negative. It is suggested that a 'normalization' of the anion gap during chemotherapy may be a useful tool to judge the efficacy of the treatment of multiple myeloma.
对26例连续的多发性骨髓瘤患者（15例IgG型和11例IgA型）进行了阴离子间隙评估。发现仅在IgG型骨髓瘤中平均联合间隙降低。相反，在IgA型骨髓瘤患者中，结果显示升高。讨论了我们的结果与其他作者结果之间的部分差异。阴离子间隙与副蛋白血症浓度之间的相关性发现（在IgA型骨髓瘤中呈正相关，在IgG型骨髓瘤中呈负相关）进一步支持了这样的概念，即IgG和IgA副蛋白在血清中表现出的电荷分别为正和负。有人提出，化疗期间阴离子间隙的“正常化”可能是判断多发性骨髓瘤治疗效果的有用工具。
