Nightingale S D, Pelley R P
Am J Hum Genet. 1981 Sep;33(5):722-34.
Ten members of 3 generations of a family have IgM-IgG cryoglobulins and rheumatoid factors in their sera; one additional member has rheumatoid factor but not cryoglobulins. The disorder occurs in an autosomal dominant pattern. Here we describe an antigen, first identified on the cryoglobulin IgM of the index case, which is present in the sera of all 11 members of this kindred with rheumatoid factor. This antigen has the serologic properties of an IgM rheumatoid factor idiotype.
一个家族三代中的10名成员血清中存在IgM-IgG冷球蛋白和类风湿因子；另有一名成员有类风湿因子，但没有冷球蛋白。该疾病以常染色体显性模式出现。在此，我们描述了一种抗原，最初在索引病例的冷球蛋白IgM上被鉴定出来，该抗原存在于这个有类风湿因子的家族的所有11名成员的血清中。这种抗原具有IgM类风湿因子独特型的血清学特性。
