口服地西泮术前用药对血气的影响。
The effects of oral diazepam premedication on blood gases.
作者信息
El Mikatti N
出版信息
Ann R Coll Surg Engl. 1981 Nov;63(6):429-31.
Abstract
Blood gas analysis was performed before and 1 h after 10 mg oral diazepam premedication on 50 adult male patients undergoing different surgical operations. There was a significant (p less than 0.01) decrease in arterial oxygen tension, a significant (p less than 0.01) increase in alveolar--arterial oxygen tension difference, and no significant change in arterial carbon dioxide tension or pH after administration of the drug. It is concluded that diazepam given by mouth 1 h before operation increases venous admixture. It is suggested therefore that oral diazepam premedication should be given cautiously to patients with impaired cardiorespiratory reserve, preferably without adding a narcotic drug.
摘要
对50例接受不同外科手术的成年男性患者，在口服10mg地西泮进行术前用药前及用药后1小时进行血气分析。给药后动脉血氧张力显著降低（p<0.01），肺泡-动脉血氧分压差显著增加（p<0.01），动脉血二氧化碳张力和pH值无显著变化。结论为术前1小时口服地西泮会增加静脉混合血。因此建议，对于心肺储备功能受损的患者，口服地西泮进行术前用药应谨慎，最好不添加麻醉药物。
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