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[产黄青霉细胞突变谱与生理状态的比率。N-亚硝基-N-甲基缩二脲在DNA复制不同阶段暴露诱导的营养缺陷型突变]

[Ratio of the mutation spectrum to the physiological state of the Penicillium chrysogenum cell. Auxotrophic mutations induced by N-nitroso-N-methylbiuret in exposure at different stages of DNA replication].

作者信息

Zakharova G M, Bartoshevich Iu E, Lebed' E S, Domracheva A G

出版信息

Antibiotiki. 1981 Aug;26(8):600-6.

PMID:6794440
Abstract

The effect of UV light on activated conidia of Penicillium chrysogenum, strain 39 was studied. It was found that the spectrum of the auxotrophic mutations induced by UV light during replication of DNA changed with the dose of the mutagen and was specific to every dose. The schemes of predominating mutation induction during DNA replication under the effect of 2 doses of UV light were developed.

摘要

研究了紫外线对产黄青霉39号菌株活化分生孢子的影响。结果发现,紫外线在DNA复制过程中诱导的营养缺陷型突变谱随诱变剂剂量的变化而变化,且每种剂量都具有特异性。制定了在2种紫外线剂量作用下DNA复制过程中主要突变诱导的方案。

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