Pitzurra L, Cenci E, Sbaraglia G, Sebastiani L
Boll Soc Ital Biol Sper. 1981 Jul 30;57(14):1517-23.
The immunogenic activity of Helix Pomatia Haemocyanin (HPH) and Octopus vulgaris Haemocyanin (OVH) has been tested in rabbits. Primary and secondary antibody response has been evaluated in sera by agar double immuno-diffusion test (Ouchterlony), counter immunoelectrophoresis and complement fixation. Bath haemocyanins proved highly antigenic: antibody titers rising up to 1/3.200 after the second antigenic challenge. The Ouchterlony test showed a partial identity between H.P.H. and O.V.H. No adverse effect was evident in injected animals.
已经在兔子身上测试了玛瑙螺血蓝蛋白（HPH）和普通章鱼血蓝蛋白（OVH）的免疫原活性。通过琼脂双向免疫扩散试验（欧氏试验）、对流免疫电泳和补体结合试验评估了血清中的初次和二次抗体反应。两种血蓝蛋白均显示出高度抗原性：在第二次抗原刺激后抗体效价升至1/3200。欧氏试验表明HPH和OVH之间存在部分同一性。在注射动物中未观察到明显的不良反应。
