单胺氧化酶、二胺氧化酶和多胺氧化酶对乙酰多胺的代谢作用。

Metabolism of acetylpolyamines by monoamine oxidase, diamine oxidase and polyamine oxidase.

作者信息

Suzuki O, Matsumoto T, Oya M, Katsumata Y

出版信息

Biochim Biophys Acta. 1981 Oct 12;677(2):190-3. doi: 10.1016/0304-4165(81)90084-2.

Abstract

N1-Monoacetylspermine, N1,N12-diacetylspermine and N1-monoacetylspermidine were found to be good substrates for rat liver polyamine oxidase, but not for rat liver mitochondrial monoamine oxidase. N8-Monoacetylspermidine, monoacetylcadaverine, monoacetylputrescine and monoacetyl-1,3-diaminopropane were oxidized by the monoamine oxidase when the substrate concentration was 10.0 mM, but not by the polyamine oxidase. All the acetylpolyamines except N1,N12-diacetylspermine were also oxidized by hog kidney diamine oxidase although their affinities for the oxidase appeared low. The present data suggest that acetylpolyamines are not easily metabolized in vivo by either monoamine oxidase or diamine oxidase in mammalian tissues although N1-monoacetylspermine, N1,N12-diacetylspermine and N1-monoacetylspermidine are attacked by polyamine oxidase.

摘要

N1-单乙酰精胺、N1,N12-二乙酰精胺和N1-单乙酰亚精胺被发现是大鼠肝脏多胺氧化酶的良好底物，但不是大鼠肝脏线粒体单胺氧化酶的底物。当底物浓度为10.0 mM时，N8-单乙酰亚精胺、单乙酰尸胺、单乙酰腐胺和单乙酰-1,3-二氨基丙烷可被单胺氧化酶氧化，但不能被多胺氧化酶氧化。除N1,N12-二乙酰精胺外，所有乙酰化多胺也可被猪肾二胺氧化酶氧化，尽管它们对该氧化酶的亲和力似乎较低。目前的数据表明，尽管N1-单乙酰精胺、N1,N12-二乙酰精胺和N1-单乙酰亚精胺会被多胺氧化酶攻击，但乙酰化多胺在哺乳动物组织中不易被单胺氧化酶或二胺氧化酶在体内代谢。