氯霉素对单胺、二胺和血浆胺氧化酶活性无影响。

Lack of effect of chloramphenicol on monoamine, diamine and plasma amine oxidase activities.

作者信息

Ali B H

出版信息

Clin Exp Pharmacol Physiol. 1985 Mar-Apr;12(2):193-5. doi: 10.1111/j.1440-1681.1985.tb02323.x.

DOI:10.1111/j.1440-1681.1985.tb02323.x

Abstract

Chloramphenicol treatment in rabbits (60 mg/kg i.m. for 5 days) did not affect significantly (P greater than 0.1) the activities of monoamine oxidase (MAO) or diamine oxidase (DAO) in liver, heart or brain. Plasma amine oxidase (PAO) was not significantly inhibited (P greater than 0.1) in goats treated with chloramphenicol (60 mg/kg i.m. for 5 days). Chloramphenicol (2 X 10(-3) mol/l) preincubated with rabbit hepatic MAO had no significant effect (P greater than 0.1) on the enzyme activity.

摘要

用氯霉素对家兔进行治疗（肌肉注射60毫克/千克，持续5天），对肝脏、心脏或大脑中的单胺氧化酶（MAO）或二胺氧化酶（DAO）的活性没有显著影响（P>0.1）。用氯霉素对山羊进行治疗（肌肉注射60毫克/千克，持续5天），血浆胺氧化酶（PAO）没有受到显著抑制（P>0.1）。用2×10⁻³摩尔/升的氯霉素与家兔肝脏MAO预孵育，对该酶活性没有显著影响（P>0.1）。