Litvitskiĭ P F
Biull Eksp Biol Med. 1981 Aug;92(8):17-20.
Experiments on 102 outbred white male rats with experimental acute transitory coronary insufficiency (ATCI) were carried out to show a consistent phasic time course of the functioning of the sympathetic cardiac activity regulation mechanism. The sympathetic neuroeffector influence on the myocardium with ATCI depends to a large measure on the intensity of the neurotransmitter biosynthesis and function of cardiomyocyte adrenoreceptors. It is suggested that the time couse of heart contractility and rhythm under ATCI is related to changes in the pre- and post-synaptic component of the sympathetic regulation mechanism of cardiac function. It is also assumed that cardiomyocyte receptors might exert a substantial influence on the possibility and development of arrhythmias. The advantages of pharmacological correction (as compared with the blockade) of sympathetic neuroeffector influences on the myocardium under ATCI are emphasized.
对102只远交系白色雄性大鼠进行实验性急性短暂性冠状动脉供血不足（ATCI）实验，以揭示交感神经心脏活动调节机制功能的一致阶段性时间进程。ATCI时交感神经效应器对心肌的影响在很大程度上取决于神经递质生物合成的强度和心肌细胞肾上腺素能受体的功能。有人认为，ATCI时心脏收缩力和节律的时间进程与心脏功能交感神经调节机制突触前和突触后成分的变化有关。还假定心肌细胞受体可能对心律失常的发生可能性和发展产生重大影响。强调了在ATCI情况下，对交感神经效应器对心肌的影响进行药理学纠正（与阻断相比）的优势。
