Vertongen F, Heyder-Bruckner C, Fondu P, Mandelbaum I
Clin Chim Acta. 1981 Oct 26;116(2):217-22. doi: 10.1016/0009-8981(81)90025-5.
A study of the haemolytic anaemia observed in protein-energy malnutrition (PEM) in Kivu disclosed the following results. The in vitro resistance to oxidative aggressions of PEM patients' erythrocytes was decreased: when incubated with acetylphenylhydrazine, a higher percentage of the cells showed Heinz bodies, as compared with erythrocytes of local controls. Normal or increased activities were found for certain erythrocyte enzymes involved in the detoxification of activated oxygen: glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glutathione reductase. The level of reduced glutathione was not decreased. Reduced activities were observed for two enzymes containing trace elements: glutathione peroxidase and superoxide dismutase. It is suggested that the shortened erythrocyte lifespan observed in PEM patients corresponds to an oxidative process which results from the decrease of both enzyme activities. The hypothesis that depletion of trace elements could be responsible for the decreased activity of those enzymes is discussed.
对基伍地区蛋白质 - 能量营养不良（PEM）患者中观察到的溶血性贫血进行的一项研究得出了以下结果。PEM患者红细胞对氧化攻击的体外抵抗力下降：与当地对照的红细胞相比，当与乙酰苯肼一起孵育时，更高比例的细胞出现海因茨小体。参与活性氧解毒的某些红细胞酶的活性正常或增加：葡萄糖 - 6 - 磷酸脱氢酶、6 - 磷酸葡萄糖酸脱氢酶和谷胱甘肽还原酶。还原型谷胱甘肽水平未降低。观察到两种含微量元素的酶活性降低：谷胱甘肽过氧化物酶和超氧化物歧化酶。有人提出，PEM患者中观察到的红细胞寿命缩短对应于一种氧化过程，该过程是由这两种酶活性降低导致的。文中讨论了微量元素缺乏可能是这些酶活性降低原因的假说。
