Mandelbaum I M, Mozes N, Fondu P
Clin Chim Acta. 1982 Sep 30;124(3):263-75. doi: 10.1016/0009-8981(82)90421-1.
Erythrocyte glycolysis has been studied in the anaemia associated with protein-energy malnutrition (PEM) in Kivu. Several results were compatible with a lowering of the mean age of the erythrocyte population, notably raised levels of glucose-6-phosphate, hexokinase, Na+-K+- adenosinetriphosphatases and potassium, and low sodium concentration. Non-significant differences were observed for glucose utilization, lactate formation, and for concentrations of fructose-6-phosphate, fructose-1,6-diphosphate, adenosine diphosphate and pyruvate kinase; there was no gross disturbance of cation transport. The level of adenosine triphosphate was slightly decreased and that of 2,3-bisphosphoglycerate was not elevated, in spite of anaemia. The latter could not be explained by an instability of this metabolite. It is concluded that slight erythrocyte glycolytic abnormalities may occur in the anaemia of Kivu PEM, but that they are not the main cause of the haemolysis observed in this syndrome.
在基伍地区，对与蛋白质 - 能量营养不良（PEM）相关的贫血症中的红细胞糖酵解进行了研究。一些结果与红细胞群体平均年龄降低相符，特别是葡萄糖 - 6 - 磷酸、己糖激酶、钠 - 钾 - 三磷酸腺苷酶和钾水平升高，以及钠浓度降低。在葡萄糖利用、乳酸形成以及果糖 - 6 - 磷酸、果糖 - 1,6 - 二磷酸、二磷酸腺苷和丙酮酸激酶浓度方面观察到无显著差异；阳离子转运没有严重紊乱。尽管存在贫血，但三磷酸腺苷水平略有下降，而2,3 - 二磷酸甘油酸水平未升高。后者不能用这种代谢物的不稳定性来解释。得出的结论是，基伍PEM贫血症中可能会出现轻微的红细胞糖酵解异常，但它们不是该综合征中观察到的溶血的主要原因。
