免疫反应基因产物抗体的体内效应。I. 用单克隆抗I-A对体液免疫反应进行单倍型特异性抑制。
In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A.
作者信息
Rosenbaum J T, Adelman N E, McDevitt H O
出版信息
J Exp Med. 1981 Nov 1;154(5):1694-702. doi: 10.1084/jem.154.5.1694.
Abstract
Immune response (Ir) gene products control immunologic function at several critical sites. We administered in vivo a monoclonal antibody reactive with I-Ak to F1 mice with the genotype H-2k/b. These treated mnice made a markedly reduced antibody response to antigen (H,G)-A--L, under the control of I-Ak, but not to antigen (T,G)-A--L, under the control of I-Ab. This relative specificity was lost if the antigen was given in complete Freund's adjuvant rather than aqueous solution. The monoclonal antibody reduced the antibody titer in an ongoing, secondary response as well. Several potential mechanisms can be postulated for this effect. This haplotypic specificity might ultimately be relevant to human disease.
摘要
免疫反应（Ir）基因产物在几个关键位点控制免疫功能。我们给基因型为H-2k/b的F1小鼠体内注射了一种与I-Ak反应的单克隆抗体。这些经过处理的小鼠对受I-Ak控制的抗原（H，G）-A--L产生的抗体反应明显降低，但对受I-Ab控制的抗原（T，G）-A--L的抗体反应没有降低。如果抗原是在完全弗氏佐剂中而不是在水溶液中给予，则这种相对特异性会丧失。该单克隆抗体也降低了正在进行的二次反应中的抗体滴度。可以推测出几种可能导致这种效应的机制。这种单倍型特异性最终可能与人类疾病相关。
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Studies on the chemical basis of the antigenicity of proteins. 5. Synthesis, characterization and immunogenicity of some multichain and linear polypeptides containing tyrosine.蛋白质抗原性的化学基础研究。5. 一些含酪氨酸的多链和线性多肽的合成、表征及免疫原性
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Mechanisms of regulation of cell-mediated immunity: anti-I-A alloantisera interfere with induction and expression of T-cell-mediated immunity to cell-bound antigen in vivo.细胞介导免疫的调节机制：抗I-A同种异体抗血清在体内干扰对细胞结合抗原的T细胞介导免疫的诱导和表达。
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Different macrophage populations distinguished by means of fluorescent polysaccharides. Recognition and properties of marginal-zone macrophages.通过荧光多糖区分不同的巨噬细胞群体。边缘区巨噬细胞的识别与特性。
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