抑制性T细胞参与针对人Ia样抗原（p23,30）的异种抗血清的免疫抑制活性。
Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30).
作者信息
Broder S, Mann D L, Waldmann T A
出版信息
J Exp Med. 1980 Jan 1;151(1):257-62. doi: 10.1084/jem.151.1.257.
Abstract
We studied the effects of an antiserum to human Ia-like antigens (p23,30) upon the polyclonal activation of normal B cells (cultured with various combination of irradiated and unirradiated T cells) to become immunoglobulin-secreting cells after stimulation with pokeweed mitogen in vitro. We found that the antiserum suppressed immunoglobulin production. The inhibitory effect did not appear to result from a simple interaction at the B-cell/monocyte level alone. Rather, the inhibitory effect required the presence of a radiosensitive subset of autologous suppressor T cells.
摘要
我们研究了抗人Ia样抗原（p23,30）抗血清对正常B细胞多克隆激活的影响（与经照射和未经照射的T细胞的各种组合一起培养），这些B细胞在体外经商陆有丝分裂原刺激后成为免疫球蛋白分泌细胞。我们发现该抗血清抑制免疫球蛋白的产生。这种抑制作用似乎并非仅由B细胞/单核细胞水平的简单相互作用所致。相反，这种抑制作用需要自体抑制性T细胞的一个对辐射敏感的亚群的存在。
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