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抑制性T细胞参与针对人Ia样抗原（p23,30）的异种抗血清的免疫抑制活性。

Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30).

作者信息

Broder S, Mann D L, Waldmann T A

出版信息

J Exp Med. 1980 Jan 1;151(1):257-62. doi: 10.1084/jem.151.1.257.

DOI:10.1084/jem.151.1.257
PMID:6444235
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185755/
Abstract

We studied the effects of an antiserum to human Ia-like antigens (p23,30) upon the polyclonal activation of normal B cells (cultured with various combination of irradiated and unirradiated T cells) to become immunoglobulin-secreting cells after stimulation with pokeweed mitogen in vitro. We found that the antiserum suppressed immunoglobulin production. The inhibitory effect did not appear to result from a simple interaction at the B-cell/monocyte level alone. Rather, the inhibitory effect required the presence of a radiosensitive subset of autologous suppressor T cells.

摘要

我们研究了抗人Ia样抗原（p23,30）抗血清对正常B细胞多克隆激活的影响（与经照射和未经照射的T细胞的各种组合一起培养），这些B细胞在体外经商陆有丝分裂原刺激后成为免疫球蛋白分泌细胞。我们发现该抗血清抑制免疫球蛋白的产生。这种抑制作用似乎并非仅由B细胞/单核细胞水平的简单相互作用所致。相反，这种抑制作用需要自体抑制性T细胞的一个对辐射敏感的亚群的存在。

相似文献

1
Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30).抑制性T细胞参与针对人Ia样抗原（p23,30）的异种抗血清的免疫抑制活性。
J Exp Med. 1980 Jan 1;151(1):257-62. doi: 10.1084/jem.151.1.257.
2
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3
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4
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Variation in the synthesis of membrane proteins of human T lymphocytes during mitogenic activation: recognition of a 70,000 dalton protein with anti-p23,30 heteroantiserum and a novel 42,000 dalton protein with anti-p44,12 heteroantiserum.有丝分裂原激活过程中人类T淋巴细胞膜蛋白合成的变化：用抗p23,30异种抗血清识别一种70,000道尔顿的蛋白，并用抗p44,12异种抗血清识别一种新的42,000道尔顿的蛋白。
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The role of interleukin 1 in human B cell activation: inhibition of B cell proliferation and the generation of immunoglobulin-secreting cells by an antibody against human leukocytic pyrogen.白细胞介素1在人B细胞活化中的作用：抗人白细胞致热原抗体对B细胞增殖及免疫球蛋白分泌细胞生成的抑制作用
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引用本文的文献

1
Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen.人类B细胞同种异体抗原DC1、MT1和LB12彼此相同，但与HLA - DR抗原不同。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4566-70. doi: 10.1073/pnas.78.7.4566.
2
Serologic identification of the human secondary B cell antigens. Correlations between function, genetics, and structure.人类二级B细胞抗原的血清学鉴定。功能、遗传学与结构之间的相关性。
J Exp Med. 1982 Sep 1;156(3):731-43. doi: 10.1084/jem.156.3.731.
3
In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A.免疫反应基因产物抗体的体内效应。I. 用单克隆抗I-A对体液免疫反应进行单倍型特异性抑制。
J Exp Med. 1981 Nov 1;154(5):1694-702. doi: 10.1084/jem.154.5.1694.
4
Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies.用抗I-A单克隆抗体治疗（新西兰黑鼠×新西兰白鼠）F1代疾病。
J Exp Med. 1983 Oct 1;158(4):1350-5. doi: 10.1084/jem.158.4.1350.
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Conversion of immunity to suppression by in vivo administration of I-A subregion-specific antibodies.通过体内给予I-A亚区特异性抗体将免疫转化为抑制。
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6
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7
Dysfunctions of pokeweed mitogen-stimulated T and B lymphocyte responses induced by gammaglobulin therapy.丙种球蛋白治疗诱导的商陆有丝分裂原刺激的T和B淋巴细胞反应功能障碍。
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8
Prevention of diabetes in nonobese diabetic mice by anti-I-A monoclonal antibodies: transfer of protection by splenic T cells.抗I-A单克隆抗体预防非肥胖糖尿病小鼠糖尿病：脾脏T细胞介导的保护作用转移
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9
Mechanism of regulation of immune responses by in vivo administration of monoclonal anti-I-A antibodies.体内给予单克隆抗I-A抗体对免疫反应的调节机制。
Surv Immunol Res. 1985;4(3):173-8. doi: 10.1007/BF02918670.

本文引用的文献

1
Immunoglobulin E in immunologic deficiency diseases. II. Serum IgE concentration of patients with acquired hypogammaglobulinemia, thymoma and hypogammaglobulinemia, myotonic dystrophy, intestinal lymphangiectasia and Wiskott-Aldrich syndrome.免疫缺陷疾病中的免疫球蛋白E。II. 获得性低丙种球蛋白血症、胸腺瘤伴低丙种球蛋白血症、强直性肌营养不良、肠淋巴管扩张症及维斯科特-奥尔德里奇综合征患者的血清IgE浓度。
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Alloantiserum-mediated suppression of histocompatibility-linked Ir-gene-controlled immune responses. Suppressive effects of IgG fragments derived from alloantisera.同种抗血清介导的组织相容性连锁Ir基因控制的免疫反应抑制。同种抗血清来源的IgG片段的抑制作用。
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3
Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.参与二次抗体应答的两种不同类型的辅助性T细胞：Ia⁺和Ia⁻辅助性T细胞的独立和协同效应
J Exp Med. 1978 Feb 1;147(2):446-58. doi: 10.1084/jem.147.2.446.
4
"Ia-like" antigens on human T cells.人类T细胞上的“Ia样”抗原。
Eur J Immunol. 1979 May;9(5):356-62. doi: 10.1002/eji.1830090504.
5
Ia-bearing T lymphocytes in man. Their identification and role in the generation of allogeneic helper activity.人体内携带Ia抗原的T淋巴细胞。它们的鉴定及其在同种异体辅助活性产生中的作用。
J Exp Med. 1978 Nov 1;148(5):1423-8. doi: 10.1084/jem.148.5.1423.
6
HLA-D associated alloantisera react with molecules similar to Ia antigens.与HLA - D相关的同种抗血清与类似于Ia抗原的分子发生反应。
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3533-6. doi: 10.1073/pnas.74.8.3533.
7
Purification and structural characterisation of human HLA-linked B-cell antigens.人类HLA连锁B细胞抗原的纯化与结构表征
Nature. 1977 Jul 21;268(5617):213-8. doi: 10.1038/268213a0.
8
Inhibition of proliferative and plaque-forming cell responses by human bone-marrow-derived lymphocytes from peripheral blood by antisera to the p23, 30 antigen.用针对p23、30抗原的抗血清抑制外周血人骨髓来源淋巴细胞的增殖和斑块形成细胞反应。
Proc Natl Acad Sci U S A. 1977 Feb;74(2):711-5. doi: 10.1073/pnas.74.2.711.
9
Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens.在混合白细胞培养中致敏的外周人T细胞合成并表达Ia样抗原。
J Exp Med. 1978 Nov 1;148(5):1440-5. doi: 10.1084/jem.148.5.1440.
10
The Sézary syndrome: a malignant proliferation of helper T cells.塞扎里综合征：辅助性T细胞的恶性增殖。
J Clin Invest. 1976 Dec;58(6):1297-306. doi: 10.1172/JCI108585.