Reuter G, Wolff I
Mol Gen Genet. 1981;182(3):516-9. doi: 10.1007/BF00293947.
Dominant suppressor mutations for position-effect variegation have been isolated by using a strongly variegated line carrying the wm4 chromosome (wm4h) and the dominant enhancer mutant En(var)c101. The use of an effective genetic test system made it possible to isolate more than 100 strongly dominant suppressor mutations for position-effect variegation. This suggests that the phenomenon of position-effect variegation is characterised by a complex genetic basis. The significance of the isolated mutants to genetic dissection of structural and regulatory functions of the eukaryotic chromosome is discussed.
通过使用携带wm4染色体（wm4h）的强斑驳品系和显性增强子突变体En(var)c101，分离出了位置效应斑驳的显性抑制突变。有效的遗传测试系统的使用使得分离出100多个位置效应斑驳的强显性抑制突变成为可能。这表明位置效应斑驳现象具有复杂的遗传基础。文中讨论了分离出的突变体对真核染色体结构和调控功能的遗传剖析的意义。
