Briant R H, Foote S E, Wallis W E
N Z Med J. 1978 Dec 27;88(626):479-82.
Of thirty-five patients with various types of epilepsy treated with sodium valproate, 15 achieved complete seizure control on that drug alone, 12 other patients benefited and eight failed to improve on the drug. Excellent results were more likely in those with petit mal epilepsy and in those whose epilepsy was controlled with other drugs at the expense of side effects. Three patients were unable to tolerate valproate, but in general few patients experienced side effects and several patients felt much better on valproate than on their previous drugs. A twice daily dosage regime was satisfactory. Plasma valproate levels at the final dose covered a wide range, 0.21 - 1.2mmol/l (34 to 190 microgram/ml) and did not correlate with response, lack of response or side effects.
在35例接受丙戊酸钠治疗的各类癫痫患者中，15例仅使用该药就实现了癫痫发作完全控制，另有12例患者病情好转，8例患者用药后未见改善。癫痫小发作患者以及那些因其他药物副作用而控制癫痫发作的患者更有可能获得良好疗效。3例患者无法耐受丙戊酸钠，但总体而言，很少有患者出现副作用，且有几名患者感觉服用丙戊酸钠比之前的药物效果好得多。每日两次的给药方案效果令人满意。末次给药时的血浆丙戊酸水平范围很广，为0.21 - 1.2mmol/l（34至190微克/毫升），且与疗效、无反应或副作用无关。
