Russell J C, Chambers M M
Physiol Chem Phys. 1981;13(3):259-65.
We have investigated the effects of chlorpheniramine (an H1 histamine inhibitor) and metiamide (an H2 inhibitor) on response to 14C pulse-labeling of carbon dioxide in the rat in the presence and absence of histamine. Neither chlorpheniramine nor metiamide alone had any effect upon the gastric venous/arterial ratio (VG/A) or the peripheral venous/arterial ratio (Vp/A). As in the case with no drug present, Vp/A rose with time following pulse-labeling to a value of 1.15-1.20. The presence of a preexisting steady-state infusion of histamine caused no changes in the ratios in the presence or absence of the inhibitors. The inhibitors did completely abolish the oscillations of both VG/A and Vp/A caused by initiation of histamine infusion coincident with the pulse-labeling. The results suggest that the histamine effects are largely mediated through H1 receptors.
我们研究了氯苯那敏（一种H1组胺抑制剂）和甲硫米特（一种H2抑制剂）在有组胺和无组胺存在的情况下，对大鼠二氧化碳14C脉冲标记反应的影响。单独使用氯苯那敏或甲硫米特对胃静脉/动脉比值（VG/A）或外周静脉/动脉比值（Vp/A）均无任何影响。与未使用药物的情况一样，脉冲标记后Vp/A随时间上升至1.15 - 1.20的值。预先存在的组胺稳态输注在有或无抑制剂的情况下，均未引起比值变化。抑制剂完全消除了与脉冲标记同时开始的组胺输注所引起的VG/A和Vp/A的振荡。结果表明，组胺的作用很大程度上是通过H1受体介导的。
