Russell J C, Chambers M M
Physiol Chem Phys. 1980;12(4):307-13.
Total carbon dioxide content of arterial, gastric venous, and peripheral venous blood of the rat has been measured by a gas extraction-gas solid chromatographic technique. In control animals total contents were 24 to 29 mmol/l and the venous/arterial ratio 1.148 +/- 0.020 (xav +/- SEM). Net change of carbon dioxide content (delta CO2) was 1.17 +/- 0.56 and 1.11 +/- 0.45 mmol/l in gastric and peripheral circulations and these were not significantly different from each other or zero. Infusion of histamine at 10 mg/kg/h led to oscillations in delta CO2 with peaks as high as 4.7 mmol/l and a period of 20 min. Similar oscillations occurred in the venous/arterial ratio with values up to 1.35. The results confirm previous reports of oscillations of carbon dioxide venous/arterial ratios induced by histamine as revealed by pulse radiolabeling experiments. The positive, if oscillatory, carbon dioxide balance in the presence of histamine supports the concept of sequestration of carbon dioxide in tissue with subsequent release on histamine stimulation.
采用气体提取-气固色谱技术测定了大鼠动脉血、胃静脉血和外周静脉血中的总二氧化碳含量。在对照动物中，总含量为24至29 mmol/l，静脉/动脉比值为1.148±0.020（平均值±标准误）。胃循环和外周循环中二氧化碳含量的净变化（δCO2）分别为1.17±0.56和1.11±0.45 mmol/l，二者之间以及与零均无显著差异。以10 mg/kg/h的速度输注组胺会导致δCO2出现振荡，峰值高达4.7 mmol/l，周期为20分钟。静脉/动脉比值也出现类似振荡，数值高达1.35。结果证实了先前关于组胺诱导二氧化碳静脉/动脉比值振荡的报道，脉冲放射性标记实验也揭示了这一点。在组胺存在的情况下，即使二氧化碳平衡呈振荡性，但其为正值，这支持了组织中二氧化碳被隔离并随后在组胺刺激下释放的概念。
