Russell J C, Chambers M M
Physiol Chem Phys. 1977;9(1):39-46.
The dynamics of carbon dioxide in both gastric and peripheral circulation of rat were studied using H14CO3--. In the absence of histamine infusion the peripheral venous/arterial ratio Vp,/A rose from less than 1.0 to almost 1.2 while the gastric ratio VG/A fell from initial values of about 2.4 to 1.2. Steady histamine infusion speeded approach of both ratios to 1.2. During transient conditions after beginning or end of histamine infusion both ratios were initially depressed to values near zero. The ratios then both rose, showing damped oscillations with a twenty-minute period. The data show a marked effect of histamine on both peripheral and gastric CO2 dynamics, even though in the resting state the two circulations have very different dynamics.
利用H¹⁴CO₃⁻研究了大鼠胃循环和外周循环中二氧化碳的动态变化。在未输注组胺时，外周静脉/动脉比Vp/A从小于1.0升至近1.2，而胃循环比VG/A则从初始值约2.4降至1.2。持续输注组胺加速了两个比值趋近于1.2。在组胺输注开始或结束后的过渡阶段，两个比值最初均降至接近零的值。随后两个比值均上升，呈现出周期为20分钟的阻尼振荡。数据表明，尽管在静息状态下两种循环的动态变化有很大差异，但组胺对外周和胃的二氧化碳动态变化均有显著影响。
