Cover B, Gutteridge W E
Trans R Soc Trop Med Hyg. 1981;75(2):274-81. doi: 10.1016/0035-9203(81)90334-5.
The sensitivity to 15 drugs of the Peru, Sonya and Y strains of Trypanosoma cruzi was investigated in inbred A/Jax strain mice. Some variation was seen in the percentage of survivors and more still in the survival times of those that died. Marked variation was seen when the two sets of data were analysed together by Litchfield's rapid graphic method for evaluating time-percent effect curves. No one strain, however, was found to be especially drug-sensitive and therefore particularly useful in primary drug screening. Furthermore, the differences in sensitivity were apparently not marked and are unlikely to have clinical significance once an effective drug with a high chemotherapeutic index is discovered for Chagas's disease.
在近交A/Jax品系小鼠中研究了克氏锥虫秘鲁株、索尼娅株和Y株对15种药物的敏感性。在存活小鼠的百分比方面存在一些差异，而在死亡小鼠的存活时间方面差异更大。当用利奇菲尔德快速图解法对两组数据进行综合分析以评估时间-效应曲线时，发现了显著差异。然而，没有发现哪一个株系对药物特别敏感，因此在初步药物筛选中特别有用。此外，敏感性差异显然不显著，一旦发现一种治疗恰加斯病的具有高化疗指数的有效药物，这些差异不太可能具有临床意义。
