Constantinou C E, Djurhuus J C
Am J Physiol. 1981 Nov;241(5):R398-411. doi: 10.1152/ajpregu.1981.241.5.R398.
The transport of urine in the upper urinary tract of the multicalyceal kidney was studied in healthy and chronically obstructed pigs in terms of renal pelvic pressure, rate of and coordination of ureteral contractions, and bolus volume. The variations of these parameters to diuresis was examined by incremental elevation of urine output effected by intravenous infusion of mannitol. In 16 healthy animals the mean variation in urine flow was 0.01-3.20 ml/min, the change in peristaltic rate ranged from 0.763 to 5.125 min-1, and bolus volume from 0.003 to 2.083 ml.. In 14 chronically obstructed kidneys, for a mean variation in urine flow of 0.006-5.4 ml/min, peristaltic rate ranged from 0.237 to 6.095 min-1 and bolus volume from 0.00 to 1.80 ml. Discoordinated contractions, bursts of peristalsis, and incompletely transmitted pelvic contractions were characteristic of a chronically obstructed system. These observations are compared with the unobstructed unicalyceal and multicalyceal kidney. The disrupting impact of chronic ureteral obstruction on the hierarchical organization of the pyeloureteral pacemaker system is discussed.
在健康猪和慢性梗阻猪中，从肾盂压力、输尿管收缩速率与协调性以及团块体积方面，对多肾盂肾的上尿路尿液输送进行了研究。通过静脉输注甘露醇增加尿量，来检查这些参数对利尿的变化。在16只健康动物中，尿流平均变化为0.01 - 3.20毫升/分钟，蠕动速率变化范围为0.763至5.125次/分钟，团块体积为0.003至2.083毫升。在14只慢性梗阻肾中，尿流平均变化为0.006 - 5.4毫升/分钟，蠕动速率范围为0.237至6.095次/分钟，团块体积为0.00至1.80毫升。不协调收缩、蠕动爆发以及不完全传递的肾盂收缩是慢性梗阻系统的特征。将这些观察结果与无梗阻的单肾盂和多肾盂肾进行了比较。讨论了慢性输尿管梗阻对肾盂输尿管起搏器系统层次组织的破坏影响。
