Riou J Y, Guibourdenche M, Courvalin P
Ann Microbiol (Paris). 1981 Jul-Aug;132B(1):23-39.
Using two different culture media we have determined, by the agar dilution method, the minimal inhibitory concentrations of five antibiotics against eighty strains of Neisseria gonorrhoeae and compared the results with those obtained with the disk-agar diffusion technique. With one medium, under defined conditions of inoculum, we found a close statistical correlation for penicillin G, cefotaxime, tetracycline and thiamphenicol with linear regression coefficients (r) ranging from --0.9457 to -0.7400 but not for spectinomycin (r = -0.2503). The technique described also allows easy detection of beta-lactamase-producing strains of gonococci.
我们使用两种不同的培养基，通过琼脂稀释法测定了五种抗生素对80株淋病奈瑟菌的最低抑菌浓度，并将结果与纸片琼脂扩散技术所得结果进行了比较。在一种培养基上，在规定的接种条件下，我们发现青霉素G、头孢噻肟、四环素和甲砜霉素具有密切的统计学相关性，线性回归系数（r）在-0.9457至-0.7400之间，但壮观霉素没有（r = -0.2503）。所描述的技术还能轻松检测出产β-内酰胺酶的淋球菌菌株。
