Pinon G, Laudat P
Ann Biol Clin (Paris). 1981;39(5):279-84.
The susceptibility of 137 isolates of Neisseria gonorrhoeae to eleven antibiotics has been determined by a disk diffusion method. For nine antibiotics (penicillin G, ampicillin, amoxicillin, cefazolin, cefoxitin, tetracycline, minocycline, erythromycin and chloramphenicol) the results were found to be similar to those of fast growing aerobic bacteria antibiogram procedures. The correlation between diameter of inhibition measured with chocolate agar 1 p. cent polyvitex BioMérieux and minimum inhibitory concentrations determined by an agar dilution procedure with GC medium 1 p. cent haemoglobin, 1 p. cent supplement B Difco was good : coefficients ranging from r = 0,78 for penicillin G to r = 0,60 for minocycline. Less satisfactory results were found if chocolate agar 1 p. cent polyvitex was substituted by Gono-Meningo medium IPP. The technique described could be used for clinical purposes and epidemiologic survey.
采用纸片扩散法测定了137株淋病奈瑟菌对11种抗生素的敏感性。对于9种抗生素（青霉素G、氨苄西林、阿莫西林、头孢唑林、头孢西丁、四环素、米诺环素、红霉素和氯霉素），结果发现与快速生长需氧菌的抗菌谱检测程序相似。用含有1%聚维生素的巧克力琼脂（生物梅里埃公司）测定的抑菌圈直径与用含有1%血红蛋白、1%补充剂B（Difco）的GC培养基通过琼脂稀释法测定的最低抑菌浓度之间具有良好的相关性：系数范围从青霉素G的r = 0.78到米诺环素的r = 0.60。如果用IPP淋病-脑膜炎培养基替代含有1%聚维生素的巧克力琼脂，结果就不那么令人满意。所描述的技术可用于临床目的和流行病学调查。
