锌离子与肝素而非其他糖胺聚糖的选择性结合。
Selective binding of zinc ions to heparin rather than to other glycosaminoglycans.
作者信息
Parrish R F, Fair W R
出版信息
Biochem J. 1981 Feb 1;193(2):407-10. doi: 10.1042/bj1930407.
Abstract
The relative binding affinity of Zn2+ to several glycosaminoglycans was determined by gel-filtration chromatography. Binding was observed only between Zn2+ and heparin. No binding was observed between Zn2+ and chondroitin 4-sulphate, chondroitin 6-sulphate, dermatan sulphate of hyaluronic acid. All of the glycosaminoglycans contained carboxy groups, but only heparin bound Zn2+. This observation suggests that, contrary to a previously proposed hypothesis, simple electrostatic interactions between the negatively charged carboxy groups of the glycosaminoglycans and the positively charged Zn2+ cannot explain the observed binding.
摘要
通过凝胶过滤色谱法测定了锌离子（Zn2+）与几种糖胺聚糖的相对结合亲和力。仅观察到Zn2+与肝素之间有结合。未观察到Zn2+与硫酸软骨素4、硫酸软骨素6、透明质酸的硫酸皮肤素之间有结合。所有糖胺聚糖都含有羧基，但只有肝素能结合Zn2+。这一观察结果表明，与之前提出的假设相反，糖胺聚糖带负电荷的羧基与带正电荷的Zn2+之间简单的静电相互作用无法解释所观察到的结合现象。
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