一种新型基于机制的酶抑制剂使胸苷酸合成酶失活：1-(β-D-2'-脱氧呋喃核糖基)8-氮杂嘌呤-2-酮5'-单磷酸。 - Suppr | 超能文献

Inactivation of thymidylate synthetase by a novel mechanism-based enzyme inhibitor: 1-(beta-D-2'-deoxyribofuranosyl) 8-azapurin-2-one 5'-monophosphate.

作者信息

Kalman T I, Goldman D

出版信息

Biochem Biophys Res Commun. 1981 Sep 30;102(2):682-9. doi: 10.1016/s0006-291x(81)80186-6.

DOI:10.1016/s0006-291x(81)80186-6

Abstract

摘要

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Inactivation of thymidylate synthetase by a novel mechanism-based enzyme inhibitor: 1-(beta-D-2'-deoxyribofuranosyl) 8-azapurin-2-one 5'-monophosphate.一种新型基于机制的酶抑制剂使胸苷酸合成酶失活：1-(β-D-2'-脱氧呋喃核糖基)8-氮杂嘌呤-2-酮5'-单磷酸。

Biochem Biophys Res Commun. 1981 Sep 30;102(2):682-9. doi: 10.1016/s0006-291x(81)80186-6.

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5-Nitro-2'-deoxyuridine 5'-monophosphate is a potent irreversible inhibitor of Lactobacillus caesi thymidylate synthetase.5-硝基-2'-脱氧尿苷5'-单磷酸是干酪乳杆菌胸苷酸合成酶的一种强效不可逆抑制剂。

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5-(alpha-Bromoacetyl)-2'-deoxyuridine 5'-phosphate: an affinity label for thymidylate synthetase.

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5-Nitro-2'-deoxyuridylate: a mechanism-based inhibitor of thymidylate synthetase.5-硝基-2'-脱氧尿苷酸：一种基于机制的胸苷酸合成酶抑制剂。

Biochem Biophys Res Commun. 1978 Oct 16;84(3):654-9. doi: 10.1016/0006-291x(78)90755-6.

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5-p-benzoquinonyl-2'-deoxyuridine 5'-phosphate: a possible mechanism-based inhibitor of thymidylate synthetase.

J Med Chem. 1983 Jul;26(7):1028-36. doi: 10.1021/jm00361a016.

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5 (alpha-bromoacetyl)-2'=deoxyuridine 5'-phosphate: a mechanism based affinity label for thymidylate synthetase.

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Essential arginyl residues in thymidylate synthetase.胸苷酸合成酶中的必需精氨酰残基。

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Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship.

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Chemical modification of Lactobacillus casei thymidylate synthetase with 1-fluoro-2,4-dinitrobenzene and 1,5-difluoro-2,4-dinitrobenzene.用1-氟-2,4-二硝基苯和1,5-二氟-2,4-二硝基苯对干酪乳杆菌胸苷酸合成酶进行化学修饰

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Interaction of 5-ethynyl-2'-deoxyuridylate with thymidylate synthetase.5-乙炔基-2'-脱氧尿苷酸与胸苷酸合成酶的相互作用。

J Med Chem. 1981 Dec;24(12):1537-40. doi: 10.1021/jm00144a036.

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