5-(alpha-Bromoacetyl)-2'-deoxyuridine 5'-phosphate: an affinity label for thymidylate synthetase.
作者信息
Brouillette C B, Chang C T, Mertes M P
出版信息
J Med Chem. 1979 Dec;22(12):1541-4. doi: 10.1021/jm00198a022.
PMID:119854
Abstract
5-(alpha-Bromoacetyl)-2'-deoxyuridine 5'-phosphate (1) is an active-site-directed irreversible inhibitor of thymidylate synthetase from Lactobacillus casei. Analysis of the rate of inactivation of the enzyme in the presence of substrate confirmed the intermediate formation of a reversible enzyme-inhibitor complex.
摘要
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