Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship.

作者信息

Wataya Y, Santi D V, Hansch C

出版信息

J Med Chem. 1977 Nov;20(11):1469-73. doi: 10.1021/jm00221a021.

DOI:10.1021/jm00221a021

PMID:410930

Abstract

摘要

相似文献

Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship.

J Med Chem. 1977 Nov;20(11):1469-73. doi: 10.1021/jm00221a021.

Inhibition of thymidylate synthetase by 5-alkynyl-2'-deoxyuridylates.

J Med Chem. 1981 Dec;24(12):1385-8. doi: 10.1021/jm00144a003.

5-Nitro-2'-deoxyuridine 5'-monophosphate is a potent irreversible inhibitor of Lactobacillus caesi thymidylate synthetase.

Biochem Biophys Res Commun. 1978 Oct 30;84(4):1054-9. doi: 10.1016/0006-291x(78)91690-x.

5-Cyano-2'-deoxyuridine 5'-phosphate: a potent competitive inhibitor of thymidylate synthetase.

J Med Chem. 1979 Sep;22(9):1137-9. doi: 10.1021/jm00195a028.

5 (alpha-bromoacetyl)-2'=deoxyuridine 5'-phosphate: a mechanism based affinity label for thymidylate synthetase.

Biochem Biophys Res Commun. 1979 Mar 30;87(2):613-8. doi: 10.1016/0006-291x(79)91838-2.

5-Nitro-2'-deoxyuridylate: a mechanism-based inhibitor of thymidylate synthetase.

Biochem Biophys Res Commun. 1978 Oct 16;84(3):654-9. doi: 10.1016/0006-291x(78)90755-6.

5-p-benzoquinonyl-2'-deoxyuridine 5'-phosphate: a possible mechanism-based inhibitor of thymidylate synthetase.

J Med Chem. 1983 Jul;26(7):1028-36. doi: 10.1021/jm00361a016.

5-(alpha-Bromoacetyl)-2'-deoxyuridine 5'-phosphate: an affinity label for thymidylate synthetase.

J Med Chem. 1979 Dec;22(12):1541-4. doi: 10.1021/jm00198a022.

Interaction of 5-ethynyl-2'-deoxyuridylate with thymidylate synthetase.

J Med Chem. 1981 Dec;24(12):1537-40. doi: 10.1021/jm00144a036.

Thymidylate synthase and fluorouracil.

Adv Exp Med Biol. 1988;244:113-24. doi: 10.1007/978-1-4684-5607-3_11.

引用本文的文献

A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers.

Cell Rep Med. 2024 Mar 19;5(3):101434. doi: 10.1016/j.xcrm.2024.101434. Epub 2024 Feb 21.

Selective therapeutic strategy for p53-deficient cancer by targeting dysregulation in DNA repair.

Commun Biol. 2021 Jul 12;4(1):862. doi: 10.1038/s42003-021-02370-0.

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.

Nucleic Acids Res. 2011 Oct;39(19):8430-44. doi: 10.1093/nar/gkr563. Epub 2011 Jul 10.

Human herpesvirus 8 gene encodes a functional thymidylate synthase.

J Virol. 2002 Oct;76(20):10530-2. doi: 10.1128/jvi.76.20.10530-10532.2002.

Interaction of tRNA (uracil-5-)-methyltransferase with NO2Ura-tRNA.

Nucleic Acids Res. 1996 Mar 15;24(6):1059-64. doi: 10.1093/nar/24.6.1059.

Antitumor activity of FTC-092, a masked 5-trifluoromethyl-2'-deoxyuridine derivative.

Cancer Chemother Pharmacol. 1991;29(2):122-6. doi: 10.1007/BF00687321.

Potentiation of the antitumor activity of 5-trifluoromethyl-2'-deoxyuridine by the use of depot forms of the parent compound.

Cancer Chemother Pharmacol. 1992;30(5):360-4. doi: 10.1007/BF00689963.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验