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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Chatelain R E, Ferrario C M

Clin Sci Mol Med. 1978 Aug;55(2):149-56. doi: 10.1042/cs0550149.

Structural changes in the thymus during the evolution experimental renal hypertension were investigated to determine their possible role in the genesis of hypertensive vascular disease. 2. The thymus, adrenal glands and the progression of hypertensive vascular lesions were investigated in rats during the first 30 days after occlusion of the aorta between the two renal arteries. 3. Hypertension was initially accompanied by marked atrophy of the thymus, most pronounced 9 days after operation. During this time, the adrenal glands doubled in size and the heart became enlarged. 4. After 21 days the thymus regenerated and became hypertrophic. Histological features of hyperactivity accompanied by infiltration of plasma cells were evident, while the adrenal glands remained enlarged. 5. The observed structural changes of the regenerated thymus in the presence of sustained adrenal hypertrophy indicate that the thymus may contribute to the production of hypertensive vascular disease.

研究了实验性肾性高血压演变过程中胸腺的结构变化，以确定其在高血压血管疾病发生中的可能作用。2. 在结扎两肾动脉之间的主动脉后的头30天内，对大鼠的胸腺、肾上腺以及高血压血管病变的进展情况进行了研究。3. 高血压最初伴有胸腺明显萎缩，术后9天最为明显。在此期间，肾上腺体积增大一倍，心脏也增大。4. 21天后，胸腺再生并肥大。伴有浆细胞浸润的活动亢进的组织学特征明显，而肾上腺仍肿大。5. 在肾上腺持续肥大的情况下，再生胸腺的结构变化表明胸腺可能促成高血压血管疾病的发生。

Chatelain R E, Ferrario C M

Clin Sci Mol Med. 1978 Aug;55(2):149-56. doi: 10.1042/cs0550149.

Structural changes in the thymus during the evolution experimental renal hypertension were investigated to determine their possible role in the genesis of hypertensive vascular disease. 2. The thymus, adrenal glands and the progression of hypertensive vascular lesions were investigated in rats during the first 30 days after occlusion of the aorta between the two renal arteries. 3. Hypertension was initially accompanied by marked atrophy of the thymus, most pronounced 9 days after operation. During this time, the adrenal glands doubled in size and the heart became enlarged. 4. After 21 days the thymus regenerated and became hypertrophic. Histological features of hyperactivity accompanied by infiltration of plasma cells were evident, while the adrenal glands remained enlarged. 5. The observed structural changes of the regenerated thymus in the presence of sustained adrenal hypertrophy indicate that the thymus may contribute to the production of hypertensive vascular disease.

研究了实验性肾性高血压演变过程中胸腺的结构变化，以确定其在高血压血管疾病发生中的可能作用。2. 在结扎两肾动脉之间的主动脉后的头30天内，对大鼠的胸腺、肾上腺以及高血压血管病变的进展情况进行了研究。3. 高血压最初伴有胸腺明显萎缩，术后9天最为明显。在此期间，肾上腺体积增大一倍，心脏也增大。4. 21天后，胸腺再生并肥大。伴有浆细胞浸润的活动亢进的组织学特征明显，而肾上腺仍肿大。5. 在肾上腺持续肥大的情况下，再生胸腺的结构变化表明胸腺可能促成高血压血管疾病的发生。