Christiansen P, Hansen U, Svendsen U G, Strandgaard S, Hegedüs V, Braendstrup O
J Hypertens. 1983 Oct;1(3):285-9. doi: 10.1097/00004872-198310000-00013.
Infarct kidney hypertension was induced in congenital athymic nude rats and in their haired normal littermates. In both groups a significant and similar elevation of blood pressure was observed. The mesenteric vessels were studied histologically five, 12 and 20 days after operation. Necrotizing vasculitis with and without perivascular inflammatory reactions was found in mesenteric arteries and arterioles in six out of six athymic and in six out of 11 control rats. In sham operated athymic rats and in haired littermates neither hypertension nor vasculitis was observed. These observations indicate that the thymus play no role in the pathogenesis of acute hypertensive vascular disease.
在先天性无胸腺裸鼠及其有毛的正常同窝仔鼠中诱发梗死性肾性高血压。在两组中均观察到血压显著且相似地升高。术后第5、12和20天对肠系膜血管进行组织学研究。在6只无胸腺大鼠中的6只以及11只对照大鼠中的6只的肠系膜动脉和小动脉中发现了伴有或不伴有血管周围炎症反应的坏死性血管炎。在假手术的无胸腺大鼠和有毛的同窝仔鼠中，既未观察到高血压也未观察到血管炎。这些观察结果表明，胸腺在急性高血压性血管疾病的发病机制中不起作用。
