[磷霉素、赖氨酸磷霉素、精氨酸磷霉素：体外抗菌活性]

[Fosfomycin, lysine-fosfomycin, arginine-fosfomycin: antibacterial activity in vitro].

作者信息

Angeretti A, Martinetto P, Valtz A

出版信息

G Batteriol Virol Immunol. 1980 Jul-Dec;73(7-12):272-80.

Abstract

The antibacterial activity of NaFosfomicin and of two of its aminoacidic derivatives -Lisin-Fosfomycin and Arginin-Fosfomycin- has been determined "in vitro" as MICs and MBCs, on different groups of Bacteria. The results obtained were then statistically analyzed - according to the "t of Student" - in a comparative evaluation of the values between NaFosfomycin-Lisin-Fosfomycin (F-LF); NaFosfomycin-Arginin-Fosfomycin (F-AF); Lisin-Fosfomycin-Arginin-Fosfomycin (LF-AF). From these comparisons, the data found demonstrated no significant differences among the three compounds, for Proteus, Coliforms and Pseudomonas groups, while Salmonella and Staphylococcus Genera showed good differences (P less than 0.05) from the comparison F-AF.

摘要

已在体外测定了磷霉素钠及其两种氨基酸衍生物（赖氨磷霉素和精氨磷霉素）对不同细菌组的抗菌活性，以最低抑菌浓度（MIC）和最低杀菌浓度（MBC）表示。然后，根据学生t检验对所得结果进行统计分析，以比较磷霉素钠 - 赖氨磷霉素（F - LF）、磷霉素钠 - 精氨磷霉素（F - AF）、赖氨磷霉素 - 精氨磷霉素（LF - AF）之间的值。通过这些比较发现，对于变形杆菌属、大肠菌群和假单胞菌属组，这三种化合物之间的数据没有显著差异，而沙门氏菌属和葡萄球菌属在F - AF比较中显示出良好的差异（P小于0.05）。