Hofmann A F, Schmuck G, Scopinaro N, Laker M F, Sherr H P, Lorenzo D, Meeuse B J
Int J Obes. 1981;5(5):513-8.
Hyperoxaluria occurs in most patients after the conventional jejunoileal bypass procedure for obesity. The mechanism of hyperoxaluria is complex, involving persistence of dietary oxalate in solution as well as increased colonic permeability to oxalate. Endogenous oxalate formation also contributes to hyperoxaluria. Treatment is unsatisfactory and involves a low-oxalate diet and simultaneous administration of agents which bind oxalate and bile acids, such as aluminum hydroxide. Hyperoxaluria was not present in 21 of 22 patients who had undergone the pancreato-biliary bypass procedure.
大多数接受传统空肠回肠分流术治疗肥胖症的患者会出现高草酸尿症。高草酸尿症的机制很复杂，包括饮食中的草酸盐在溶液中持续存在以及结肠对草酸盐的通透性增加。内源性草酸盐的形成也会导致高草酸尿症。治疗效果并不理想，包括低草酸盐饮食以及同时服用结合草酸盐和胆汁酸的药物，如氢氧化铝。在接受胰胆分流术的22名患者中，有21名未出现高草酸尿症。
