Kishi H, Yamaji A, Kataoka K, Fujii Y, Nishikawa K, Ohnishi N, Hiraoka E, Okada A, Kim C W
JPEN J Parenter Enteral Nutr. 1981 Sep-Oct;5(5):420-3. doi: 10.1177/0148607181005005420.
Studies were undertaken to determine rational dosages of vitamin A and E during long-term total parenteral nutrition (TPN). Four kinds of vitamin prescriptions containing different amounts of vitamin A and E were prepared from commercially available products and/or hospital pharmacy products. Patients were divided into four groups according to the vitamin prescription used. Plasma vitamin levels of different patient groups were determined by a modified fluorimetric method and were compared with those of a normal subject group. The stability of vitamin A and E in TPN solution after admixing was determining by measuring the remaining vitamin contents by high pressure liquid chromatography. From the results, it was concluded that 1) about 50% of vitamin A was decomposed by sunlight (about 2000 lux) 3 hr after admixing and an orange-colored vinyl cover could protect its photodecomposition; 2) vitamin E was stable at any condition tested; 3) 2500 IU of vitamin A and 15 IU of vitamin E could meet the daily requirements; 4) the plasma levels of vitamin A and E were correlative (p less than 0.01); and 5) concomitant administration of vitamin E was essential to keep the poorer level of vitamin A in plasma.
开展了多项研究以确定长期全胃肠外营养（TPN）期间维生素A和维生素E的合理剂量。从市售产品和/或医院药房产品中制备了四种含有不同量维生素A和维生素E的维生素处方。根据所使用的维生素处方将患者分为四组。采用改良荧光法测定不同患者组的血浆维生素水平，并与正常受试者组进行比较。通过高压液相色谱法测量剩余维生素含量来确定混合后TPN溶液中维生素A和维生素E的稳定性。从结果得出以下结论：1）混合后3小时，约50%的维生素A被阳光（约2000勒克斯）分解，橙色乙烯基覆盖物可保护其光分解；2）维生素E在任何测试条件下均稳定；3）2500国际单位的维生素A和15国际单位的维生素E可满足每日需求；4）维生素A和维生素E的血浆水平相关（p小于0.01）；5）同时给予维生素E对于维持血浆中较低水平的维生素A至关重要。
