Clements I P, Brown M L, Smith H C
Mayo Clin Proc. 1981 Dec;56(12):733-9.
Count rates observed at end-diastole and end-systole in the region of the left ventricle on gated radionuclide angiograms were correlated with corresponding estimates by biplane contrast angiography of left ventricular volumes in 37 patients. When count rates were normalized for number of cardiac cycles processed, time per frame, isotope decay, and count rate observed in venous blood after equilibrium, there was a strong correlation between normalized left ventricular count rate and contrast angiographic volume, whether the venous sample was counted in a well counter or with the use of the same gamma camera. The latter technique was judged easier and more accurate. The derived regression equations yielded a good estimate of ventricular volume from left ventricular count rates when prospectively compared with contrast angiographic volumes in a further 17 patients. Interobserver variability of both the radionuclide and the contrast angiographic estimate of the left ventricular volume was similar. Changes in left ventricular stroke volume induced by sublingual administration of nitroglycerin as measured by the radionuclide method correlated reasonably with corresponding changes in stroke volume measured by the dye-dilution method. It is concluded that left ventricular volumes obtained noninvasively by the radionuclide technique were accurate and were subject to the same interobserver variability as the contrast angiographic technique.
在37例患者中，门控放射性核素血管造影左心室区域舒张末期和收缩末期观察到的计数率与双平面对比血管造影对左心室容积的相应估计值相关。当对处理的心动周期数、每帧时间、同位素衰变以及平衡后静脉血中观察到的计数率进行计数率标准化后，无论静脉样本是在井型计数器中计数还是使用同一伽马相机计数，标准化左心室计数率与对比血管造影容积之间均存在强相关性。后一种技术被认为更简便且更准确。当与另外17例患者的对比血管造影容积进行前瞻性比较时，推导的回归方程根据左心室计数率对心室容积进行了良好估计。放射性核素和对比血管造影对左心室容积估计的观察者间变异性相似。通过放射性核素法测量，舌下含服硝酸甘油引起的左心室每搏量变化与染料稀释法测量的相应每搏量变化合理相关。结论是，放射性核素技术无创获得的左心室容积准确，且与对比血管造影技术具有相同的观察者间变异性。
