Guichard M, Tenforde T, Curtis S, Malaise E P
Radiology. 1982 Jan;142(1):219-23. doi: 10.1148/radiology.142.1.6796997.
The response to accelerated neon ions of human Nall melanomas growing in nude mice was measured by an in vitro colony-forming assay following in situ tumor irradiation in the midposition of a 10-cm extended-peak ionization region. Values of the relative biological effectiveness (RBE) for peak neon ions compared with 60Co gamma radiation were 3.2 and 3.4, respectively, at the 1% and 10% survival levels. Following irradiation with peak neon ions, the repair of potentially lethal damage (PLD) was comparable to that observed after gamma irradiation. When misonidazole (1 mg/g intraperitoneal dose) was administered in combination with extended-peak neon ions, the drug enhancement ratio (ER) at the 1% survival level was 1.5 if the tumors were removed and plated in vitro immediately following irradiation, and 1.9 if tumor excision and plating were delayed for greater than 6 hours. Administration of misonidazole completely inhibited PLD repair following either gamma irradiation or extended-peak neon-ion irradiation.
通过体外集落形成试验，对裸鼠体内生长的人黑色素瘤在10厘米扩展峰电离区域中部进行原位肿瘤照射后，测量其对加速氖离子的反应。与60Coγ射线相比，在1%和10%存活水平下，峰氖离子的相对生物效应（RBE）值分别为3.2和3.4。在用峰氖离子照射后，潜在致死损伤（PLD）的修复与γ射线照射后观察到的情况相当。当腹腔注射米索硝唑（1毫克/克剂量）与扩展峰氖离子联合使用时，如果照射后立即切除肿瘤并进行体外接种，在1%存活水平下的药物增强率（ER）为1.5；如果肿瘤切除和接种延迟超过6小时，则ER为1.9。米索硝唑的给药完全抑制了γ射线照射或扩展峰氖离子照射后的PLD修复。
