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氖离子对EMT6肿瘤系统的相对生物效能(RBE)和氧增强比(OER)

The relative biological effectiveness (RBE) and oxygen enhancement ratio (OER) of neon ions for the EMT6 tumor system.

作者信息

Fu K K, Phillips T L

出版信息

Radiology. 1976 Aug;120(2):439-41. doi: 10.1148/120.2.439.

DOI:10.1148/120.2.439
PMID:935502
Abstract

EMT6 tumors were exposed to neon ions in vivo and in vitro in the plateau and spread-out Bragg peak regions of the beam. The RBE in vivo was 1.7-2.1 in the plateau region and 2.6-2.9 in the Bragg peak; the OER was 2.0 and 1.4, respectively. Neon ions have great potential in the radiotherapy of tumors because of their decreased OER and excellent depth-dose distribution in tissue.

摘要

EMT6肿瘤在体内和体外接受了位于束流的坪区和扩展布拉格峰区的氖离子照射。体内坪区的相对生物效应(RBE)为1.7 - 2.1,布拉格峰区为2.6 - 2.9;氧增强比(OER)分别为2.0和1.4。由于氖离子降低的OER以及在组织中优异的深度剂量分布,其在肿瘤放射治疗中具有巨大潜力。

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引用本文的文献

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Effect of tumor dissaggregation on results of in vitro cell survival assay after in vivo treatment of the EMT-6 tumor: x-rays, cyclophosphamide, and bleomycin.肿瘤解离对体内治疗EMT-6肿瘤后体外细胞存活试验结果的影响:X射线、环磷酰胺和博来霉素。
In Vitro. 1980 Jul;16(7):547-53. doi: 10.1007/BF02618377.