Steen P A, Milde J H, Michenfelder J D
Acta Anaesthesiol Scand. 1981 Aug;25(4):319-22. doi: 10.1111/j.1399-6576.1981.tb01659.x.
Pentoxifylline 0.3--30 mg/kg was given intravenously to six dogs under nitrous oxide anesthesia. Cerebral blood flow was measured with a sagittal sinus outflow technique, cerebral oxygen consumption was calculated from the a-v difference, and metabolite levels were determined in biopsies of cerebral cortex. Pentoxifylline failed to influence cerebral blood flow or oxygen consumption. There was no increase in cerebral levels of phosphocreatine, ATP or total adenine nucleotides; the only significant effect was higher glucose levels in dogs given pentoxifylline (4.49 +/- 0.39 mumol/g vs 2.21 +/- 0.18 mumol/g). The latter has previously been reported to be deleterious during cerebral ischemia. Pentoxifylline thus failed to have any significant influence upon cerebral blood flow or metabolism in the dog likely to be of benefit during cerebral hypoxia or ischemia.
在氧化亚氮麻醉下，给6只狗静脉注射3 - 30毫克/千克的己酮可可碱。采用矢状窦流出技术测量脑血流量，根据动静脉血氧差计算脑氧耗量，并测定大脑皮质活检组织中的代谢物水平。己酮可可碱未能影响脑血流量或氧耗量。脑内磷酸肌酸、三磷酸腺苷（ATP）或总腺嘌呤核苷酸水平没有升高；唯一显著的影响是给予己酮可可碱的狗脑内葡萄糖水平较高（4.49±0.39微摩尔/克对2.21±0.18微摩尔/克）。此前有报道称，后者在脑缺血期间是有害的。因此，己酮可可碱对狗的脑血流量或代谢没有任何显著影响，而在脑缺氧或缺血期间可能有益。
