Bowton D L, Stump D A, Prough D S, Toole J F, Lefkowitz D S, Coker L
Department of Anesthesia (Critical Care), Wake Forest University Medical Center, Winston-Salem, North Carolina.
Stroke. 1989 Dec;20(12):1662-6. doi: 10.1161/01.str.20.12.1662.
We determined the immediate effects of pentoxifylline on cerebral blood flow in 10 patients with cerebrovascular disease; four received 400 mg and six received 800 mg pentoxifylline orally. Regional cerebral blood flow was measured before (baseline) and 2, 4, and 6 hours after pentoxifylline administration using the xenon-133 clearance technique with 16 detectors (eight per hemisphere). Global cerebral blood flow as a percentage of the baseline value increased significantly after 800 mg but not 400 mg pentoxifylline (p = 0.017 and p = 0.29, respectively). Regional cerebral blood flow as a percentage of the baseline value at the detector with the lowest baseline value increased significantly 2 hours after both 400 mg and 800 mg pentoxifylline (p = 0.038 and p = 0.010, respectively). Cerebrovascular reactivity to carbon dioxide was preserved despite the increases in cerebral blood flow. Pentoxifylline increases cerebral blood flow and is not associated with "intracerebral steal" in patients with cerebrovascular disease.
我们测定了己酮可可碱对10例脑血管疾病患者脑血流量的即时影响；4例口服400毫克己酮可可碱，6例口服800毫克己酮可可碱。使用带有16个探测器（每侧半球8个）的氙-133清除技术，在服用己酮可可碱前（基线）以及服用后2、4和6小时测量局部脑血流量。800毫克己酮可可碱后，全脑血流量占基线值的百分比显著增加，而400毫克己酮可可碱后则未增加（分别为p = 0.017和p = 0.29）。在基线值最低的探测器处，400毫克和800毫克己酮可可碱后2小时，局部脑血流量占基线值的百分比均显著增加（分别为p = 0.038和p = 0.010）。尽管脑血流量增加，但对二氧化碳的脑血管反应性仍得以保留。己酮可可碱可增加脑血管疾病患者的脑血流量，且与“脑内窃血”无关。
