Koppenhagen K, Wenig H G, Müller K
Curr Med Res Opin. 1976;4(10):681-7. doi: 10.1185/03007997609112002.
A double-blind, placebo controlled crossover study was carried out in 20 geriatric patients with cerebrovascular insufficiency ot asses the effect of pentoxifylline on cerebral blood flow. Using 99m Tc cerebral scinitigraphy and a gamma comera/computer system, the pattern of blood flow in 5 brain areas was manitored after a single intravenous infusion of 200 mg pentoxifylline (10 ml) and after 10 ml saline solution. The results showed that, with the exception of one brain area, there was a statistically significant increase both in regional and hemispheric cerebral blood flow after pentoxifylline. It is of particular interst that global hemispheric blood flow, which gives an indication of total blood supply to the brain, showed approximately the same percentage increase on both sides with pentoxifylline.
对20名患有脑血管供血不足的老年患者进行了一项双盲、安慰剂对照的交叉研究，以评估己酮可可碱对脑血流量的影响。使用99m锝脑闪烁扫描法和γ相机/计算机系统，在单次静脉输注200毫克己酮可可碱（10毫升）后以及输注10毫升盐溶液后，监测5个脑区的血流模式。结果显示，除一个脑区外，己酮可可碱治疗后局部和半球脑血流量均有统计学意义的增加。特别有趣的是，反映大脑总供血情况的全半球血流量在己酮可可碱治疗后两侧增加的百分比大致相同。
