Vileisis R A, Deddish R B, Fitzsimons E, Hunt C E
Am J Clin Nutr. 1981 Dec;34(12):2653-7. doi: 10.1093/ajcn/34.12.2653.
Weekly serum zinc levels during the neonatal period have been obtained in 17 preterm infants randomly assigned to a prospective feeding study. Nine neonates received a standard regimen of naso-jejunal feedings (group I) and eight matched infants received total parenteral nutrition (group II) for the first 2 wk, followed by enteral intake for the last 2 wk of the study period. No patient received supplemental zinc intake. Base-line serum zinc levels obtained before beginning feedings at 2 days of age were in the normal range and not significantly different, 121 +/- 15 and 135 +/- 8 micrograms/dl in groups I and II, respectively (mean +/- SEM). Serial serum zinc levels decreased progressively in both groups during the 4-wk study period, reaching a low of 80 +/- 7 micrograms/dl in group I and 85 +/- 10 micrograms/dl in group II. The progressive decline in serum zinc levels is postulated to be indicative of tissue depletion of zinc. Our data suggest that preterm infants fed either by short-term total parenteral nutrition or by transpyloric enteral feedings are at risk for marginal zinc deficiency states.
在一项前瞻性喂养研究中，对17名随机分组的早产儿在新生儿期每周测定血清锌水平。9名新生儿接受鼻空肠喂养标准方案（第一组），8名匹配的婴儿在前2周接受全胃肠外营养（第二组），在研究期的最后2周改为肠内摄入。没有患者接受锌补充剂。在2日龄开始喂养前测得的基线血清锌水平在正常范围内，且两组间无显著差异，第一组和第二组分别为121±15和135±8微克/分升（均值±标准误）。在为期4周的研究期间，两组的血清锌水平均逐渐下降，第一组降至80±7微克/分升的低点，第二组降至85±10微克/分升的低点。血清锌水平的逐渐下降被认为表明锌在组织中的消耗。我们的数据表明，短期接受全胃肠外营养或经幽门肠内喂养的早产儿有边缘性锌缺乏状态的风险。
