Winqvist I, Olsson I, Werner S, Stenstam M
Allergy. 1981 Aug;36(6):419-23. doi: 10.1111/j.1398-9995.1981.tb01848.x.
Challenge tests were performed in patients with food intolerance and allergic rhinitis to evaluate the usefulness of measurement of the eosinophil cationic protein (ECP) of serum to distinguish different allergic reactions. In one group of patients with food intolerance symptom-induced challenge resulted in a marked decrease of serum-ECP. The number of blood eosinophils decreased simultaneously in some but not all of these patients. In another group of patients with food intolerance serum-ECP displayed peak-like increases followed by a decrease. The decrease in serum-ECP may reflect that consumption of ECP is a result of idiosyncrasy in the target organ. In allergic rhinitis some patients showed an initial peak-like increase of serum-ECP, which was abolished by pretreatment with disodium-cromoglycate but not by pretreatment with antihistamine. Similar results have previously been demonstrated for allergic asthma. The difference obtained in serum-ECP upon challenge in typical reagin-mediated allergy and food intolerance may indicate that the latter is not reagin-mediated. However, the interpretation of data is difficult because of lack of knowledge regarding the turnover in the circulation of ECP.
对食物不耐受和过敏性鼻炎患者进行激发试验，以评估检测血清嗜酸性粒细胞阳离子蛋白（ECP）对于区分不同过敏反应的有用性。在一组有食物不耐受症状的患者中，激发试验导致血清ECP显著降低。部分但并非全部患者的血液嗜酸性粒细胞数量同时减少。在另一组食物不耐受患者中，血清ECP呈峰值样升高后下降。血清ECP的降低可能反映了靶器官中特异性反应导致ECP的消耗。在过敏性鼻炎中，一些患者血清ECP最初呈峰值样升高，用色甘酸钠预处理可消除这种升高，但用抗组胺药预处理则不能。此前在过敏性哮喘中也得到了类似结果。在典型的反应素介导的过敏和食物不耐受激发试验中血清ECP的差异可能表明后者不是由反应素介导的。然而，由于缺乏关于ECP在循环中的周转情况的知识，数据解释存在困难。
