Bachert C, Becker W, Ganzer U
HNO-Klinik, Klinikum Mannheim, Universität Heidelberg, Federal Republic of Germany.
Arch Otorhinolaryngol. 1989;246(4):173-82. doi: 10.1007/BF00453657.
Findings in recent years have stressed the importance of research on the target organ in IgE-mediated allergies of the respiratory tract. In this review we have focussed on the nasal secretions (NS) as a contract medium between allergens and the respiratory mucosa. Our findings have demonstrated that NS show different allergen extraction activities in relation to different conditions. Whereas NS of allergic and inflamed noses extracted allergens very rapidly, NS of normal noses showed no extraction activity. Furthermore, it could be demonstrated that the IgE specificities in NS are comparable with those in the serum of individual patients not indicating a local IgE synthesis. The presence and function of basophilic cells and eosinophils and their mediators are discussed in the light of recent studies.
近年来的研究结果强调了对呼吸道IgE介导的过敏反应中靶器官进行研究的重要性。在本综述中，我们重点关注鼻分泌物（NS）作为变应原与呼吸道黏膜之间的接触介质。我们的研究结果表明，在不同条件下，NS表现出不同的变应原提取活性。过敏性和发炎鼻子的NS能非常迅速地提取变应原，而正常鼻子的NS则没有提取活性。此外，可以证明NS中的IgE特异性与个体患者血清中的IgE特异性相当，这表明不存在局部IgE合成。根据最近的研究，对嗜碱性粒细胞和嗜酸性粒细胞及其介质的存在和功能进行了讨论。
