Belianchikova N I, Vornovitskaia G I, Khramtsova S N, Shapot V S
Biull Eksp Biol Med. 1981 Oct;91(10):476-8.
The growth of allogeneic ascites hepatoma is accompanied by involution of the thymus, leukemoid response and anemia. Tumor cells disseminate throughout the body appearing in many organs including the spleen, liver, bone marrow and lymph nodes. The activity of adenosine deaminase and the adenosine deaminase/purine nucleosidephosphorylase ratio decrease in the host thymus as well as in the cellular elements of the spleen. The above phenomena reflect the impairment of lymphocyte differentiation and presumably contribute to the decreased efficiency of the host immune response.
同种异体腹水肝癌的生长伴随着胸腺退化、类白血病反应和贫血。肿瘤细胞扩散至全身，出现在包括脾脏、肝脏、骨髓和淋巴结在内的许多器官中。宿主胸腺以及脾脏细胞成分中的腺苷脱氨酶活性和腺苷脱氨酶/嘌呤核苷磷酸化酶比值降低。上述现象反映了淋巴细胞分化受损，可能导致宿主免疫反应效率降低。
