化学刺激物对大变形虫细胞膜的一些影响。
Some effects of chemical irritants on the membrane of the giant amoeba.
作者信息
Foster R W, Weston A H, Weston K M
出版信息
Br J Pharmacol. 1981 Oct;74(2):333-9. doi: 10.1111/j.1476-5381.1981.tb09976.x.
1 The effects of chemical irritants on the membrane potential and input resistance of the giant amoeba, Chaos carolinense, have been investigated. The membrane potential and input resistance were -111.5 mV and 8.6 M pi respectively. 2 In the resting state the cell membrane of Chaos carolinense was found to be impermeable to Na+ but permeable to K+. The distribution of K+ across the cell membrane conformed to a Donnan equilibrium with the resting membrane potential being the K+ equilibrium potential. 3 The chemical irritants dibenzoxazepine and its 2-chloro- and 3-chloro-analogues and o-chlorobenzylidene malononitrile produced a fall in input resistance but no change in membrane potential. It is suggested that these effects are caused by an increase in K+ permeability. 4 The potencies of a series of chemical irritants with respect to dibenzoxazepine were measured on the giant amoeba. These potencies did not reflect those found in mammalian preparations.
- 研究了化学刺激物对大型变形虫卡罗林纳混沌虫膜电位和输入电阻的影响。膜电位和输入电阻分别为 -111.5 mV 和 8.6 MΩ。2. 在静息状态下，发现卡罗林纳混沌虫的细胞膜对 Na+ 不可渗透，但对 K+ 可渗透。K+ 在细胞膜两侧的分布符合唐南平衡，静息膜电位为 K+ 平衡电位。3. 化学刺激物二苯并恶唑嗪及其 2 -氯和 3 -氯类似物以及邻氯亚苄基丙二腈导致输入电阻下降，但膜电位无变化。提示这些效应是由 K+ 通透性增加引起的。4. 在大型变形虫上测定了一系列化学刺激物相对于二苯并恶唑嗪的效力。这些效力与在哺乳动物制剂中发现的效力不同。
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