胰岛素通过介导肽的蛋白水解形成发挥作用的化学机制。 - Suppr

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Chemical mechanism of insulin action via proteolytic formation of mediator peptides.

作者信息

Larner J, Cheng K, Schwartz C, Dubler R, Creacy S, Kikuchi K, Tamura S, Galasko G, Pullin C, Katz M

出版信息

Mol Cell Biochem. 1981 Nov 13;40(3):155-61. doi: 10.1007/BF00224609.

DOI:10.1007/BF00224609

PMID:6798421

Abstract

摘要

相似文献

Chemical mechanism of insulin action via proteolytic formation of mediator peptides.胰岛素通过介导肽的蛋白水解形成发挥作用的化学机制。

Mol Cell Biochem. 1981 Nov 13;40(3):155-61. doi: 10.1007/BF00224609.

Independent control of selected insulin-sensitive cell membrane and intracellular functions-the linkage of cell membrane and intracellular events controlled by insulin. III. The influence of trypsin on cell membrane hexose transport and on glycogen synthase and mitochondrial pyruvate dehydrogenase activation.对选定的胰岛素敏感细胞膜和细胞内功能的独立控制——胰岛素控制的细胞膜与细胞内事件的联系。III. 胰蛋白酶对细胞膜己糖转运、糖原合酶及线粒体丙酮酸脱氢酶激活的影响。

Mol Cell Biochem. 1981 Jul 7;37(2):125-30. doi: 10.1007/BF02354936.

Insulin mediators and their control of metabolism through protein phosphorylation.胰岛素介质及其通过蛋白质磷酸化对代谢的调控。

Recent Prog Horm Res. 1982;38:511-56. doi: 10.1016/b978-0-12-571138-8.50017-2.

Intracellular mediators of insulin action.

Diabetes Metab Rev. 1985;1(3):229-59. doi: 10.1002/dmr.5610010302.

New perspectives on the mechanism of insulin action.胰岛素作用机制的新观点。

Recent Prog Horm Res. 1984;40:347-77. doi: 10.1016/b978-0-12-571140-1.50013-x.

Insulin mediators from rat skeletal muscle have differential effects on insulin-sensitive pathways of intact adipocytes.

Science. 1985 Feb 1;227(4686):533-5. doi: 10.1126/science.3917578.

Production by plasma membranes of a chemical mediator of insulin action.胰岛素作用的化学介质由质膜产生。

Fed Proc. 1982 Sep;41(11):2730-5.

Modulation of hexose uptake and insulin action by cell membrane fluidity. The effects of temperature on membrane fluidity, insulin action, and insulin binding.细胞膜流动性对己糖摄取和胰岛素作用的调节。温度对膜流动性、胰岛素作用及胰岛素结合的影响。

J Biol Chem. 1979 Apr 25;254(8):2619-25.

Characterization of mediators of insulin action.

Ann N Y Acad Sci. 1986;488:385-405. doi: 10.1111/j.1749-6632.1986.tb46573.x.

Evidence that insulin activates an intrinsic plasma membrane protease in generating a secondary chemical mediator.有证据表明胰岛素在生成次级化学介质时会激活一种内在质膜蛋白酶。

J Biol Chem. 1980 Jul 25;255(14):6529-31.

引用本文的文献

Biosynthesis of the endogenous cyclic adenosine monophosphate (AMP) antagonist, prostaglandylinositol cyclic phosphate (cyclic PIP), from prostaglandin E and activated inositol polyphosphate in rat liver plasma membranes.大鼠肝细胞膜中由前列腺素E和活化的肌醇多磷酸生物合成内源性环磷酸腺苷（AMP）拮抗剂环前列腺素肌醇磷酸酯（环PIP）。

Acta Diabetol. 1996 Jul;33(2):126-38. doi: 10.1007/BF00569423.

Effects of theophylline on insulin receptors and insulin action in the adipocyte.茶碱对脂肪细胞中胰岛素受体及胰岛素作用的影响。

Mol Cell Biochem. 1983;57(2):177-83. doi: 10.1007/BF00849194.

Evidence for surface glycoprotein involvement in the intracellular bioactivity of insulin in rat adipocytes.表面糖蛋白参与大鼠脂肪细胞中胰岛素细胞内生物活性的证据。

Biochem J. 1983 Jul 15;214(1):111-20. doi: 10.1042/bj2140111.

Insulin-induced factors derived from lymph node cells influence anaphylactoid reaction in the rat.源自淋巴结细胞的胰岛素诱导因子影响大鼠的类过敏反应。

Agents Actions. 1983 Jun;13(4):283-7. doi: 10.1007/BF01971479.

Further evidence for the involvement of a membrane proteolytic step in insulin action.胰岛素作用中膜蛋白水解步骤参与的进一步证据。

Biochem J. 1985 Apr 1;227(1):137-47. doi: 10.1042/bj2270137.

The effect of insulinomimetic agents on protein degradation in H35 hepatoma cells.

Mol Cell Biochem. 1986 Aug;71(2):159-66. doi: 10.1007/BF00214775.

Influence of a small molecular weight proteinase inhibitor, gabexate mesilate (FOY), on insulin receptor function in vitro.

Int J Pancreatol. 1988 Mar;3(2-3):135-42. doi: 10.1007/BF02798924.

本文引用的文献

The magnitude of signal amplification by ligand-induced receptor clustering.配体诱导的受体聚集导致的信号放大程度。

Nature. 1981 Jan 22;289(5795):322-3. doi: 10.1038/289322a0.

Insulin as a potent, specific growth factor in a rat hepatoma cell line.胰岛素作为大鼠肝癌细胞系中的一种强效、特异性生长因子。

Science. 1981 Feb 27;211(4485):947-9. doi: 10.1126/science.7008195.

Effects of peptide hormones and adrenergic agents on membrane potentials of target cells.肽类激素和肾上腺素能药物对靶细胞膜电位的影响。

Fed Proc. 1981 Feb;40(2):121-4.

Effects of insulin, catecholamines, and cyclic nucleotides on rat adipocyte membrane potential.

J Biol Chem. 1981 Jan 25;256(2):649-55.

Isolation from rat adipocytes of a chemical mediator for insulin activation of pyruvate dehydrogenase.从大鼠脂肪细胞中分离出一种用于胰岛素激活丙酮酸脱氢酶的化学介质。

Diabetes. 1980 Oct;29(10):852-5. doi: 10.2337/diacare.20.10.852.

Cultured hepatoma cells as a model system for studying insulin processing and biologic responsiveness.培养的肝癌细胞作为研究胰岛素加工和生物反应性的模型系统。

Diabetes. 1980 Nov;29(11):865-74. doi: 10.2337/diab.29.11.865.

Hyperpolarization as a mediator of insulin action: increased muscle glucose uptake induced electrically.超极化作为胰岛素作用的介质：电诱导增加肌肉对葡萄糖的摄取。

Am J Physiol. 1980 Jul;239(1):E21-9. doi: 10.1152/ajpendo.1980.239.1.E21.

J Biol Chem. 1980 Jul 25;255(14):6529-31.

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.胰岛素对分离的大鼠脂肪细胞葡萄糖转运作用的潜在机制。细胞内转运系统向质膜的明显易位。

J Biol Chem. 1980 May 25;255(10):4758-62.

Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated plasma membrane/mitochondria mixture: evidence for generated of insulin's second messenger in a subcellular system.通过直接向分离的质膜/线粒体混合物中添加胰岛素来激活丙酮酸脱氢酶：亚细胞系统中胰岛素第二信使生成的证据。

Proc Natl Acad Sci U S A. 1980 Jan;77(1):77-81. doi: 10.1073/pnas.77.1.77.

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