硫酸软骨素和透明质酸对培养的动脉内皮细胞糖胺聚糖和胶原蛋白合成及分泌的影响。
The effect of chondroitin-sulfate and hyaluronic acid on glycosaminoglycan and collagen synthesis and secretion by cultured arterial endothelial cells.
作者信息
Bihari-Varga M, Csonka E, Gruber E, Jellinek H
出版信息
Pathol Biol (Paris). 1981 Nov;29(9):562-6.
The effect of the addition of chondroitin-sulfate or hyaluronic acid to the culture medium on the glycosaminoglycan and collagen content and on the glycosaminoglycan composition of pig arterial endothelial cells and of the culture medium has been studied by biochemical and morphological methods. Both chondroitin-sulfate and hyaluronic acid were found to be transported to the interior of the cultured cells and then degraded. CSA, in addition enhanced collagen synthesis within the cells, but not the rate of excretion. Hyaluronic acid did not influence collagen formation.
通过生化和形态学方法研究了在培养基中添加硫酸软骨素或透明质酸对猪动脉内皮细胞及培养基中糖胺聚糖、胶原蛋白含量以及糖胺聚糖组成的影响。发现硫酸软骨素和透明质酸均被转运至培养细胞内部并随后降解。此外，硫酸软骨素增强了细胞内胶原蛋白的合成，但不影响其排泄速率。透明质酸不影响胶原蛋白的形成。
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