Socol M L, Manning F A, Murata Y, Druzin M L
Am J Obstet Gynecol. 1982 Jan 15;142(2):214-8. doi: 10.1016/s0002-9378(16)32339-0.
Cigarette smoking during pregnancy has been related to poor perinatal outcome. To investigate the changes in maternal and fetal arterial blood gases associated with smoking, five chronically catheterized pregnant rhesus monkeys were exposed to standard cigarette smoking (N = 5) and nicotine-free herbal cigarette smoke (N = 3). The only consistently reproducible and significant finding was a drop in fetal PO2. The timing of the decline in PO2 and the similar responses to standard and nicotine-free cigarette smoke make carboxyhemoglobin the most likely causative factor.
孕期吸烟与不良围产期结局有关。为了研究与吸烟相关的母体和胎儿动脉血气变化，对五只长期插管的怀孕恒河猴进行了实验，其中五只暴露于标准香烟烟雾（N = 5），三只暴露于不含尼古丁的草药香烟烟雾（N = 3）。唯一一致可重复且显著的发现是胎儿PO2下降。PO2下降的时间以及对标准香烟烟雾和不含尼古丁的香烟烟雾的类似反应使得碳氧血红蛋白成为最可能的致病因素。
