Wallace S, Chuang V P, Samuels M, Johnson D
Cancer. 1982 Feb 15;49(4):640-5. doi: 10.1002/1097-0142(19820215)49:4<640::aid-cncr2820490406>3.0.co;2-6.
Bilateral internal iliac artery infusion of chemotherapeutic agents in patients with advanced bladder carcinoma, Stage D, resulted in a 50% response or greater in nine of 15 patients with a median survival, thus far, of 52 weeks. Hematuria was controlled in eight of ten patients, and pain was relieved in 12 of 15 patients. Three additional patients were treated as adjuvants after their residual tumor was removed surgically or irradiated before chemotherapy. Cis-diamminedichloroplatinum (CDDP) was infused at a dose of 80--120 mg/m2 over a 24-hour period. When CDDP failed or in the presence of impaired renal function, a combination of 5-fluorouracil (5-FU) infused intraarterially while Adriamycin and mitomycin C were delivered intravenously, salvaged two patients. Complications were tolerable, consisting of transient acute tubular necrosis in two patients, a lower extremity embolus in one, and skin reactions due to 5-FU in two patients.
对15例D期晚期膀胱癌患者进行双侧髂内动脉化疗药物灌注，15例中有9例出现50%或更高的缓解率，截至目前，中位生存期为52周。10例患者中有8例血尿得到控制，15例患者中有12例疼痛缓解。另外3例患者在化疗前手术切除或放疗残留肿瘤后作为辅助治疗。顺二氯二氨铂（CDDP）在24小时内以80-120mg/m²的剂量输注。当CDDP治疗失败或存在肾功能损害时，5-氟尿嘧啶（5-FU）动脉内输注，同时阿霉素和丝裂霉素C静脉给药，挽救了2例患者。并发症可以耐受，包括2例患者出现短暂急性肾小管坏死，1例出现下肢栓塞，2例患者出现5-FU引起的皮肤反应。
