Hirose S, Hamashima Y
Eur J Pediatr. 1978 Aug 17;129(1):17-27. doi: 10.1007/BF00441370.
Twenty-seven skin biopsies were obtained from the exanthemata of patients in the acute stage of the mucocutaneous lymph node syndrome (MCLS). The three vascular systems of different caliber size--the intrapapillary capillary loops (ICL), the superficial arteriolar or venular plexus (SAP, SVP) and the small subcutaneous vessels--were examined to investigate the characteristics of the vasculitis in MCLS and differentiate it from infantile polyarteritis nodosa (IPN). Significant papillary edema and dilatation of ICL, SAP and SVP were observed on the 4th day after the onset of the illness, and then gradually decreased. In the subcutaneous regions, vasculitis began with endothelial necrosis, and subendothelial edema and degenerative changes in the muscle cells followed. These changes in the small subcutaneous vessels were observed for a longer period than in the ICL, SAP and SVP. Moderate mononuclear cell infiltrations were observed. Both arteries and veins were affected.
从皮肤黏膜淋巴结综合征（MCLS）急性期患者的皮疹处获取了27份皮肤活检样本。研究不同管径大小的三种血管系统——乳头内毛细血管袢（ICL）、浅表小动脉或小静脉丛（SAP、SVP）以及皮下小血管——以探讨MCLS中血管炎的特征，并将其与婴儿结节性多动脉炎（IPN）相鉴别。发病后第4天观察到ICL、SAP和SVP有明显的乳头水肿和扩张，随后逐渐减轻。在皮下区域，血管炎始于内皮细胞坏死，随后出现内皮下水肿和肌细胞退行性改变。皮下小血管的这些变化比ICL、SAP和SVP持续的时间更长。观察到中度单核细胞浸润。动脉和静脉均受累。
