Zumoff B, Strain G W, Kream J, O'Connor J, Rosenfeld R S, Levin J, Fukushima D K
J Clin Endocrinol Metab. 1982 Mar;54(3):534-8. doi: 10.1210/jcem-54-3-534.
The 24-h mean plasma concentrations of androgens (dihydrotestosterone and total and free testosterone), estrogens (estrone and estradiol), and gonadotropins (LH and FSH) were measured in 35 healthy men, aged 21-85 yr, who were rigorously screened to exclude factors known or suspected to alter endocrine function. The plasma total testosterone concentration showed a slow continuous decline with age, decreasing about 35% between 21 and 85 yr of age; the free testosterone level was closely correlated with that of total testosterone over the entire observed concentration range. The concentrations of dihydrotestosterone, estrone, estradiol, and LH were age invariant. The concentration of FSH showed a continuous linear increase with age; the level at age 85 was about 2.5 times the level at age 21. The following conclusions were drawn. 1) Testosterone secretion appears to decline slowly and continuously throughout adult life in men. 2) Measurement of the plasma free testosterone level adds no independent information in healthy men, since its level is closely correlated with that of total testosterone at all concentrations. 3) The continuous rise with age in FSH concentration while LH is age invariant cannot be explained by changes in testosterone or estrogen production, but might be due to a decline of inhibin production with age.
对35名年龄在21至85岁的健康男性进行了检测，测量了雄激素（双氢睾酮、总睾酮和游离睾酮）、雌激素（雌酮和雌二醇）以及促性腺激素（促黄体生成素和促卵泡生成素）的24小时平均血浆浓度。这些男性经过严格筛选，以排除已知或疑似会改变内分泌功能的因素。血浆总睾酮浓度随年龄增长呈缓慢持续下降，在21岁至85岁之间下降约35%；在整个观察到的浓度范围内，游离睾酮水平与总睾酮水平密切相关。双氢睾酮、雌酮、雌二醇和促黄体生成素的浓度不随年龄变化。促卵泡生成素的浓度随年龄呈持续线性增加；85岁时的水平约为21岁时的2.5倍。得出以下结论：1）男性在成年期睾酮分泌似乎会缓慢持续下降。2）在健康男性中，测量血浆游离睾酮水平并不能提供独立信息，因为其水平在所有浓度下都与总睾酮水平密切相关。3）促卵泡生成素浓度随年龄持续上升而促黄体生成素不随年龄变化，这无法用睾酮或雌激素产生的变化来解释，可能是由于抑制素产生随年龄下降所致。
