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埃塞俄比亚产后妇女月经恢复时间、空间分布及预测因素:基于2016年埃塞俄比亚人口与健康调查数据的冈珀茨逆高斯共享脆弱模型证据

Time to Resumption of Menses, Spatial Distribution, and Predictors Among Post-partum Period Women in Ethiopia, Evidence From Ethiopian Demographic and Health Survey 2016 Data: Gompertz Inverse Gaussian Shared Frailty Model.

作者信息

Belay Daniel Gashaneh, Asratie Melaku Hunie

机构信息

Department of Human Anatomy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Department of Epidemiology and Biostatistics, College of Medicine and Health Sciences, Institute of Public Health, University of Gondar, Gondar, Ethiopia.

出版信息

Front Reprod Health. 2022 May 13;4:862693. doi: 10.3389/frph.2022.862693. eCollection 2022.

DOI:10.3389/frph.2022.862693
PMID:36303667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9580771/
Abstract

BACKGROUND

The timing of the resumption of post-partum menses is important for a woman who intends to avoid subsequent unintended pregnancy, and it has key implications on maternal, neonatal, and child health outcomes. Despite this, information is scant about the time to resumption of post-partum menses and predictors in Ethiopia. Therefore, this study aimed to determine the time it takes to start menses and spatial distribution among post-partum period women in Ethiopia and identify its predictors.

METHODS

A secondary data analysis was conducted based on 2016 Ethiopian Demographic and Health Survey (EDHS). A total weighted sample of 6,489 post-partum women was included in the analysis. STATA 14 was used to weigh, clean, and analyze the data. The shared frailty model was applied since the EDHS data have a hierarchical nature. For checking the proportional hazard assumption, the Schenefold residual test, Log-Log plot, Kaplan-Meier, and predicted survival plot were applied. Akakie Information Criteria (AIC), Cox-Snell residual test, and deviance were used for checking model adequacy and for model comparison. Based on these, the Gompertz inverse Gaussian shared frailty model was the best-fitted model for this data. Variables with a < 0.2 were considered for the multivariable Gompertz inverse Gaussian shared frailty model. Finally, the adjusted hazard ratio () with a 95% confidence interval (), and a < 0.05 was reported to identify the significant predictors of time to the resumption of post-partum menses.

RESULTS

The median survival time to post-partum menses resumption was 14.6 months. In this study, 51.90% [95% : 50.03, 53.76] of post-partum period women had resumed, and the risk of menses resumption was 1.17 times [: 1.17; 95% : 1.03-1.33] higher among urban resident, 1.14 times [: 1.14; 95% : 1.0-1.24] in women who had attended formal education, and 1.63 times [: 1.63; 95% : 1.4-1.7] higher among women who used hormonal contraceptives. However, the risk of post-partum menses resumption was lower among 7-24 months breastfeeding women by 36% [: 0.64; 95% : 0.5-0.76], women with child alive by 26% [: 0.74; 95% : 0.6-0.85], and multiparous women by 27% [: 0.73; 95% : 0.6-0.80].

CONCLUSION

Almost half of the participants had resumed post-partum menses, with the median survival timing of menses resumption at 14.5 months. Women residing in urban areas, who attended formal education, and using hormonal contraceptives have a shorter time to resume post-partum menses, whereas a woman with an alive child, breastfeeding practice, and multiple parity has a longer time to resume post-partum menses. Therefore, the healthcare providers and program managers should act on the resumption of post-partum menses through health education and promotion to cultivate the 14 months lag period identified by considering the significant factors.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223e/9580771/e7df44aadd77/frph-04-862693-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223e/9580771/8f1cc6ab38a1/frph-04-862693-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223e/9580771/31198532f297/frph-04-862693-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223e/9580771/25ba1142dd0f/frph-04-862693-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223e/9580771/e7df44aadd77/frph-04-862693-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223e/9580771/8f1cc6ab38a1/frph-04-862693-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223e/9580771/31198532f297/frph-04-862693-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223e/9580771/25ba1142dd0f/frph-04-862693-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/223e/9580771/e7df44aadd77/frph-04-862693-g0004.jpg
摘要

背景

对于想要避免后续意外怀孕的女性而言,产后月经恢复的时间很重要,并且对孕产妇、新生儿及儿童的健康结局有着关键影响。尽管如此,在埃塞俄比亚,关于产后月经恢复时间及其预测因素的信息却很少。因此,本研究旨在确定埃塞俄比亚产后女性月经恢复的时间及其在产后阶段的空间分布,并找出其预测因素。

方法

基于2016年埃塞俄比亚人口与健康调查(EDHS)进行二次数据分析。分析纳入了总计6489名产后女性的加权样本。使用STATA 14对数据进行加权、清理和分析。由于EDHS数据具有分层性质,因此应用了共享脆弱模型。为检验比例风险假设,应用了谢恩费尔德残差检验、对数-对数图、卡普兰-迈耶法和预测生存图。使用赤池信息准则(AIC)、考克斯-斯内尔残差检验和偏差来检验模型的充分性并进行模型比较。基于这些,冈珀茨逆高斯共享脆弱模型是对此数据拟合度最好的模型。对于多变量冈珀茨逆高斯共享脆弱模型,考虑p<0.2的变量。最后,报告调整后的风险比(HR)及其95%置信区间(CI),以及p<0.05的结果,以确定产后月经恢复时间的显著预测因素。

结果

产后月经恢复的中位生存时间为14.6个月。在本研究中,51.90%[95%CI:50.03,53.76]的产后女性月经已恢复,城市居民月经恢复的风险高1.17倍[HR:1.17;95%CI:1.03 - 1.33],接受过正规教育的女性高1.14倍[HR:1.14;95%CI:1.0 - 1.24],使用激素避孕的女性高1.63倍[HR:1.63;95%CI:1.4 - 1.7]。然而,7至24个月哺乳期女性产后月经恢复的风险低36%[HR:0.64;95%CI:0.5 - 0.76],有存活子女的女性低26%[HR:0.74;95%CI:0.6 - 0.85],经产妇低27%[HR:0.73;95%CI:0.6 - 0.80]。

结论

几乎一半的参与者已恢复产后月经,月经恢复的中位生存时间为14.5个月。居住在城市地区、接受过正规教育且使用激素避孕的女性产后月经恢复时间较短,而有存活子女、进行母乳喂养和多产的女性产后月经恢复时间较长。因此,医疗服务提供者和项目管理者应通过健康教育和促进措施来应对产后月经恢复问题,考虑到这些重要因素,利用所确定的14个月间隔期。

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