Paganini M, Zaccara G, Moroni F, Campostrini R, Bendoni L, Arnetoli G, Zappoli R
Eur J Clin Pharmacol. 1987;32(2):219-22. doi: 10.1007/BF00542201.
The concentrations of valproic acid (VPA) and of its metabolites 3-oxo-VPA and 4-en-VPA were measured in the plasma of 12 selected epileptic patients 1, 2, 3, and 4 h after administration of a loading dose of VPA. Four of the patients, all on polytherapy, had had short-term adverse effects during chronic VPA treatment, and in them there has been abnormal NH3-values after a test doese of VPA. Eight patients (4 on monotherapy and 4 on polytherapy) had been free from adverse effects. No significant difference in the VPA, 3-oxo-VPA and 4-en-VPA concentrations was found between the three groups of patients. Accumulation of 4-en-VPA is not involved in the short-term adverse effects and hyperammonaemia induced by VPA.
在12名选定的癫痫患者静脉注射负荷剂量丙戊酸（VPA）后1、2、3和4小时，测定其血浆中丙戊酸（VPA）及其代谢产物3-氧代-VPA和4-烯-VPA的浓度。其中4名患者均接受联合治疗，在慢性VPA治疗期间出现短期不良反应，且在给予试验剂量的VPA后，他们的氨值异常。8名患者（4名单药治疗，4名联合治疗）未出现不良反应。三组患者之间的VPA、3-氧代-VPA和4-烯-VPA浓度无显著差异。4-烯-VPA的蓄积与VPA引起的短期不良反应和高氨血症无关。
