小鼠胸腺细胞-脑抗原分子上存在霍乱原受体的证据。
Evidence for the presence of choleragen receptor on the thymocyte-brain antigen molecule of mice.
作者信息
Thiele H G, Arndt R, Stark R
出版信息
Immunology. 1977 May;32(5):767-70.
Abstract
CBA thymocytes were subjected to cocapping experiments using AThy-1.2 and choleragen. The finding that both structures showed a common ligant-induced redistribution implies that choleragen receptors of the cell membrane are associated with the thymocyte-brain molecule. Furthermore, it was found that the thymocyte-brain antigenic determinants on the thymocyte were not blocked by prior choleragen treatment. This suggests a spatial distance between these structures on the molecule.
摘要
将CBA胸腺细胞用抗Thy-1.2和霍乱毒素进行共帽实验。两种结构均显示出常见的配体诱导再分布这一发现表明，细胞膜的霍乱毒素受体与胸腺细胞-脑分子相关联。此外，还发现胸腺细胞上的胸腺细胞-脑抗原决定簇不会被预先的霍乱毒素处理所阻断。这表明分子上这些结构之间存在空间距离。
相似文献
1
Evidence for the presence of choleragen receptor on the thymocyte-brain antigen molecule of mice.小鼠胸腺细胞-脑抗原分子上存在霍乱原受体的证据。
Immunology. 1977 May;32(5):767-70.
2
3
Solubilization and molecular characterization of membrane-bound antigens shared by thymocytes and brain.胸腺细胞和脑共有的膜结合抗原的溶解及分子特征分析
Eur J Immunol. 1976 May;6(5):333-40. doi: 10.1002/eji.1830060506.
4
Detection and molecular characterization of the thymus-brain antigen in human brain.人类大脑中胸腺-脑抗原的检测及分子特征分析。
Immunology. 1977 Jul;33(1):101-7.
5
6
Three ways of using immunology to investigate the cell surface: cocapping, helper determinants and immunogenicity.利用免疫学研究细胞表面的三种方法：共帽法、辅助决定簇和免疫原性。
Johns Hopkins Med J Suppl. 1974;3:425-33.
7
8
9
Antigenic correlations between brain and thymus. III. Reciprocal blocking of antigenic determinants on mouse brain and thymocytes by anti-mouse-brain- and anti-thy-1.2 sera.脑与胸腺之间的抗原相关性。III. 抗小鼠脑血清和抗Thy-1.2血清对小鼠脑和胸腺细胞上抗原决定簇的相互封闭作用
Z Immunitatsforsch Exp Klin Immunol. 1974 Feb;146(4):360-9.
10
The relationship between cholera toxin receptor and the Thy-1 antigen determinants.霍乱毒素受体与Thy-1抗原决定簇之间的关系。
Isr J Med Sci. 1978 Aug;14(8):876-81.
引用本文的文献
1
Shared antigenic determinants between brain and thymus-derived lymphocytes in dogs.犬脑源性淋巴细胞和胸腺源性淋巴细胞之间的共同抗原决定簇。
Acta Neuropathol. 1981;54(1):75-82. doi: 10.1007/BF00691334.
2
Pathophysiological effects of Vibrio cholerae and enterotoxigenic Escherichia coli and their exotoxins on eucaryotic cells.霍乱弧菌和产肠毒素大肠杆菌及其外毒素对真核细胞的病理生理作用。
Microbiol Rev. 1978 Sep;42(3):592-613. doi: 10.1128/mr.42.3.592-613.1978.
3
Independent mobility of cholera toxin binding sites and Thy-1 alloantigen on mouse thymocytes.霍乱毒素结合位点与小鼠胸腺细胞上Thy-1同种抗原的独立移动性。
Immunology. 1978 Jul;35(1):183-8.
本文引用的文献
1
Brain and thymus lipid inhibition of antibrain-associated theta-cytotoxicity.脑和胸腺脂质对脑相关θ细胞毒性的抑制作用。
J Exp Med. 1974 Feb 1;139(2):445-50. doi: 10.1084/jem.139.2.445.
2
Gangliosides and membrane receptors for cholera toxin.神经节苷脂与霍乱毒素膜受体
Biochemistry. 1973 Aug 28;12(18):3558-66. doi: 10.1021/bi00742a032.
3
Isolation and characterization of a molecular complex containing Thy-1 antigen from the surface of murine thymocytes and T cells.从小鼠胸腺细胞和T细胞表面分离并鉴定含Thy-1抗原的分子复合物。
Eur J Immunol. 1973 Jul;3(7):446-53. doi: 10.1002/eji.1830030714.
4
Isolation of theta antigen from the surface of thymus lymphocytes.从胸腺淋巴细胞表面分离θ抗原。
Nat New Biol. 1973 Feb 21;241(112):251-2. doi: 10.1038/newbio241251a0.
5
Antigenic correlations between brain and thymus. I. Common antigenic structures in rat and mouse brain tissue and thymocytes.脑与胸腺之间的抗原相关性。I. 大鼠和小鼠脑组织与胸腺细胞中的共同抗原结构。
Eur J Immunol. 1972 Oct;2(5):424-9. doi: 10.1002/eji.1830020508.
6
Interaction of cholera toxin and toxin derivatives with lymphocytes. I. Binding properties and interference with lectin-induced cellular stimulation.霍乱毒素及其衍生物与淋巴细胞的相互作用。I. 结合特性及对凝集素诱导的细胞刺激的干扰
J Exp Med. 1974 Apr 1;139(4):801-19. doi: 10.1084/jem.139.4.801.
7
Preliminary characterization of Thy-1.1 and Ag-B antigens from rat tissues solubilized in detergents.对用去污剂溶解的大鼠组织中Thy-1.1和Ag-B抗原的初步表征。
Biochem J. 1974 Oct;143(1):51-61. doi: 10.1042/bj1430051.
8
9
10
Ligand-induced redistribution of lymphocyte membrane ganglioside GM1.配体诱导的淋巴细胞膜神经节苷脂GM1的重新分布。
Nature. 1975 Sep 11;257(5522):103-6. doi: 10.1038/257103a0.
Zotero 插件